Evidence map›Paper›PMID 33918997›Full record

ReviewBiomolecules2021

Iron Deficiency in Obesity and after Bariatric Surgery.

Geir Bjørklund, Massimiliano Peana, Lyudmila Pivina, Alexandru Dosa, Jan Aaseth, Yuliya Semenova, Salvatore Chirumbolo, Serenella Medici, Maryam Dadar, Daniel-Ovidiu Costea

Open access · goldAbstract readReview
In one paragraph

Review in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 3 pooled it
11.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 3 syntheses or guidelines pooled it, 85 citations in OpenAlex.

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  18. Abdominoplasty and rectus diastasis repair-a plastic surgeon's perspective.Hernia : the journal of hernias and abdominal wall surgery · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 5 countries.

Geir BjørklundCouncil for Nutritional and Environmental Medicine, Toften 24, 8610 Mo i Rana, Norway.ORCID 0000-0003-2632-3935
Massimiliano PeanaDepartment of Chemistry and Pharmacy, University of Sassari, Via Vienna 2, 07100 Sassari, Italy.ORCID 0000-0002-3306-0419
Lyudmila PivinaDepartment of Neurology, Ophthalmology and Otolaryngology, Semey Medical University, 071400 Semey, Kazakhstan.
Alexandru DosaFaculty of Medicine, Ovidius University of Constanta, 900470 Constanta, Romania.ORCID 0000-0001-8782-6718
Jan AasethResearch Department, Innlandet Hospital Trust, 2380 Brumunddal, Norway.ORCID 0000-0002-7518-5703
Yuliya SemenovaDepartment of Neurology, Ophthalmology and Otolaryngology, Semey Medical University, 071400 Semey, Kazakhstan.
Salvatore ChirumboloDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37134 Verona, Italy.ORCID 0000-0003-1789-8307
Serenella MediciDepartment of Chemistry and Pharmacy, University of Sassari, Via Vienna 2, 07100 Sassari, Italy.
Maryam DadarRazi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj 31975/148, Iran.ORCID 0000-0001-5831-801X
Daniel-Ovidiu CosteaFaculty of Medicine, Ovidius University of Constanta, 900470 Constanta, Romania.
Ovidius University · ROSemey Medical University · KZUniversity of Sassari · ITInnlandet Hospital Trust · NORazi Vaccine and Serum Research Institute · IRThe Research Council of Norway · NOUniversity of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Iron deficiency (ID) is particularly frequent in obese patients due to increased circulating levels of acute-phase reactant hepcidin and adiposity-associated inflammation. Inflammation in obese subjects is closely related to ID. It induces reduced iron absorption correlated to the inhibition of duodenal ferroportin expression, parallel to the increased concentrations of hepcidin. Obese subjects often get decreased inflammatory response after bariatric surgery, accompanied by decreased serum hepcidin and therefore improved iron absorption. Bariatric surgery can induce the mitigation or resolution of obesity-associated complications, such as hypertension, insulin resistance, diabetes mellitus, and hyperlipidemia, adjusting many parameters in the metabolism. However, gastric bypass surgery and sleeve gastrectomy can induce malabsorption and may accentuate ID. The present review explores the burden and characteristics of ID and anemia in obese patients after bariatric surgery, accounting for gastric bypass technique (Roux-en-Y gastric bypass-RYGB) and sleeve gastrectomy (SG). After bariatric surgery, obese subjects' iron status should be monitored, and they should be motivated to use adequate and recommended iron supplementation.

Indexed as

Iron DeficienciesAnemiaAnemia, Iron-DeficiencyBariatric SurgeryDietary SupplementsGastrectomyGastric BypassHepcidinsHumansIronObesityHepcidinsIronbariatric surgeryiron deficiencyiron metabolismiron supplementobesity

Identifiers

PMID33918997
PMCPMC8142987
OpenAlexW3156714477

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.