ArticlePlants (Basel, Switzerland)2021
Anti-Obesity Effect of Pine Needle Extract on High-Fat Diet-Induced Obese Mice.
Article in Plants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 14 citations in OpenAlex.
- Comparative Bioactivities and Fatty Acid Composition ofLife (Basel, Switzerland) · 2025Article
- The potential role of hypothalamic POMCExperimental & molecular medicine · 2025Article
- Anti-Obesity and Weight Management-Related Antioxidant Potential Properties of Calabrian Pine Extracts:Plants (Basel, Switzerland) · 2025Article
- Isolation, characterization, and LC MS/MS determination of anti-obesity components from pine needles ofFrontiers in nutrition · 2024Article
- Adiposity Reduction byNutrients · 2023Article
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundObesity due to an excessive intake of nutrient disturbs the hypothalamus-mediated energy metabolism subsequently develops metabolic disorders. In this study, we investigated the effect of pine needle extract (PNE) on the hypothalamic proopiomelanocortin (POMC) neurons involved in the regulation of energy balance via melanocortin system and fat tissue metabolism.
methodsWe performed electrophysiological and immunohistochemical analyses to determine the effect of PNE on POMC neurons. Mice were fed a normal or high-fat diet for 12 weeks, then received PNE for the last 2 weeks to measure the following physiological indices: Body weight, food intake, fat/lean mass, glucose metabolism, and plasma leptin levels. In addition, changes of thermogenic, lipolytic, and lipogenetic markers were evaluated in brown adipose tissue (BAT) and white adipose tissue (WAT) by western blotting, respectively.
resultsPNE increased hypothalamic POMC neuronal activity, and the effect was abolished by blockade of melanocortin 3/4 receptors (MC3/4Rs). PNE decreased body weight, fat mass, plasma leptin levels, and improved glucose metabolism after high-fat-induced obesity. However, PNE did not change the expression of thermogenic markers of the BAT in HFD fed groups, but decreased only the lipogenetic markers of WAT. This study suggests that PNE has a potent anti-obesity effect, inhibiting lipogenesis in WAT, even though HFD-induced leptin resistance-mediated disruption of POMC neuronal activity.
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