Evidence map›Paper›PMID 33919617›Full record

ArticleMicroorganisms2021

Enteric Ganglioneuritis, a Common Feature in a Subcutaneous TBEV Murine Infection Model.

Mathias Boelke, Christina Puff, Kathrin Becker, Fanny Hellhammer, Frederic Gusmag, Hannah Marks, Katrin Liebig, Karin Stiasny, Gerhard Dobler, Wolfgang Baumgärtner and 2 more

Open access · goldAbstract read
In one paragraph

Article in Microorganisms, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Flaviviruses-Induced Neurological Sequelae.Pathogens (Basel, Switzerland) · 2024
    Review
  6. Article
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Mathias BoelkeDepartment of Infectious Diseases, Institute for Parasitology, University of Veterinary Medicine, Buenteweg 17, 30559 Hanover, Germany.
Christina PuffDepartment of Pathology, University of Veterinary Medicine, Buenteweg 17, 30559 Hanover, Germany.ORCID 0000-0002-2592-6868
Kathrin BeckerDepartment of Pathology, University of Veterinary Medicine, Buenteweg 17, 30559 Hanover, Germany.ORCID 0000-0002-0922-8189
Fanny HellhammerDepartment of Infectious Diseases, Institute for Parasitology, University of Veterinary Medicine, Buenteweg 17, 30559 Hanover, Germany.
Frederic GusmagDepartment of Infectious Diseases, Institute for Parasitology, University of Veterinary Medicine, Buenteweg 17, 30559 Hanover, Germany.
Hannah MarksDepartment of Pathology, University of Veterinary Medicine, Buenteweg 17, 30559 Hanover, Germany.
Katrin LiebigDepartment of Infectious Diseases, Institute for Parasitology, University of Veterinary Medicine, Buenteweg 17, 30559 Hanover, Germany.
Karin StiasnyDepartment of Virology, Medical University of Vienna, Kinderspitalgasse 15, 1090 Vienna, Austria.ORCID 0000-0002-1902-8674
Gerhard DoblerInstitute of Microbiology of the Bundeswehr, Neuherbergstraße 11, 80937 Munich, Germany.
Wolfgang BaumgärtnerDepartment of Pathology, University of Veterinary Medicine, Buenteweg 17, 30559 Hanover, Germany.
Claudia SchulzResearch Center for Emerging Infections and Zoonoses, Buenteweg 17, 30559 Hanover, Germany.ORCID 0000-0003-4614-618X
Stefanie C BeckerDepartment of Infectious Diseases, Institute for Parasitology, University of Veterinary Medicine, Buenteweg 17, 30559 Hanover, Germany.
University of Veterinary Medicine Hannover, Foundation · DEMedical University of Vienna · ATUniversität der Bundeswehr München · DE

Funding

Bundesministeriums für Bildung und Forschung 01KI1728ABundesministeriums für Bildung und Forschung FKZ 01KI1728FMinistry of Science and Culture of Lower Saxony N-RENNT
6 · The paper itself

Abstract

Tick-borne encephalitis (TBE) is a severe neurologic disease in Europe and Asia. Disease expression ranges from asymptomatic to severe neurological clinical pictures, involving meningitis, encephalitis, meningoencephalitis and potentially fatal outcome. Humans mostly become infected with TBE virus (TBEV) by the bite of an infected tick. Gastrointestinal (GI) symptoms in humans are mainly attributed to the first viremic phase of TBEV infection with unspecific symptoms and/or resulting from severe neurological impairment of the central nervous system (CNS). We used the subcutaneous TBEV-infection of C57BL/6 mice as a model to analyze GI complications of TBE. We observed the acute distension and segmental dilation of the intestinal tract in 10 of 22 subcutaneously infected mice. Histological analysis revealed an intramural enteric ganglioneuritis in the myenteric and submucosal plexus of the small and large intestine. The numbers of infiltrating macrophages and CD3

Indexed as

enteric nervous systemganglioneuritistick-borne encephalitis virusT lymphocytes

Identifiers

PMID33919617
PMCPMC8074024
OpenAlexW3156022811

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.