Evidence map›Paper›PMID 33920113›Full record

ArticleMolecules (Basel, Switzerland)2021

Design, Synthesis, and Validation of a Novel [

Clayton A Whitmore, Mariam I Boules, William J Behof, Justin R Haynes, Dmitry Koktysh, Adam J Rosenberg, Mohammed N Tantawy, Wellington Pham

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Clayton A WhitmoreVanderbilt University Medical Center, Vanderbilt University Institute of Imaging Science, Nashville, TN 37232, USA.
Mariam I BoulesVanderbilt University Medical Center, Vanderbilt University Institute of Imaging Science, Nashville, TN 37232, USA.
William J BehofVanderbilt University Medical Center, Vanderbilt University Institute of Imaging Science, Nashville, TN 37232, USA.
Justin R HaynesVanderbilt University Medical Center, Vanderbilt University Institute of Imaging Science, Nashville, TN 37232, USA.
Dmitry KoktyshDepartment of Chemistry, Vanderbilt University, VU Station, Nashville, TN 37235, USA.
Adam J RosenbergVanderbilt University Medical Center, Vanderbilt University Institute of Imaging Science, Nashville, TN 37232, USA.ORCID 0000-0003-2459-7043
Mohammed N TantawyVanderbilt University Medical Center, Vanderbilt University Institute of Imaging Science, Nashville, TN 37232, USA.
Wellington PhamVanderbilt University Medical Center, Vanderbilt University Institute of Imaging Science, Nashville, TN 37232, USA.
Vanderbilt University Medical Center · USVanderbilt University · US

Funding

Validation of Retinal Abeta as a Potential Biomarker of Alzheimer's DiseaseR01AG061138 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PHAM, WELLINGTON · 2019 to 2023
$3.6M
NIA NIH HHS R01 AG061138NIH HHS AG061138
6 · The paper itself

Abstract

Promethazine, an antihistamine drug used in the clinical treatment of nausea, has been demonstrated the ability to bind Abeta in a transgenic mouse model of Alzheimer's disease. However, so far, all of the studies were performed in vitro using extracted tissues. In this work, we report the design and synthesis of a novel [

Indexed as

Alzheimer DiseaseAnimalsAutoradiographyBrainHumansMicePlaque, AmyloidPositron-Emission TomographyPromethazineRadiochemistryRadiopharmaceuticalsPromethazineRadiopharmaceuticalsAbetaAlzheimerautoradiographyPET imagingpromethazine

Identifiers

PMID33920113
PMCPMC8070574
OpenAlexW3153323669

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.