Evidence map›Paper›PMID 33921143›Full record

ArticleMetabolites2021

Urinary Metabolites Enable Differential Diagnosis and Therapeutic Monitoring of Pediatric Inflammatory Bowel Disease.

Mai Yamamoto, Meera Shanmuganathan, Lara Hart, Nikhil Pai, Philip Britz-McKibbin

Open access · goldAbstract read
In one paragraph

Article in Metabolites, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. ERJ open research · 2025
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  7. The Immune Regulation of Melanin FromFood science & nutrition · 2025
    Article
  8. Review
  9. Article
  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Mai YamamotoDepartment of Chemistry and Chemical Biology, McMaster University, Hamilton, ON L8S 4M1, Canada.ORCID 0000-0003-0344-2747
Meera ShanmuganathanDepartment of Chemistry and Chemical Biology, McMaster University, Hamilton, ON L8S 4M1, Canada.
Lara HartDepartment of Pediatrics, Division of Pediatric Gastroenterology and Nutrition, McMaster University, Hamilton, ON L8S 4K1, Canada.
Nikhil PaiDepartment of Pediatrics, Division of Pediatric Gastroenterology and Nutrition, McMaster University, Hamilton, ON L8S 4K1, Canada.ORCID 0000-0002-7537-6059
Philip Britz-McKibbinDepartment of Chemistry and Chemical Biology, McMaster University, Hamilton, ON L8S 4M1, Canada.ORCID 0000-0001-9296-3223
McMaster University · CAPopulation Health Research Institute · CA

Funding

Canadian Association of Gastroenterology/Shire Pharma Canada Resident Research Grant xGenome Canada xNatural Sciences and Engineering Research Council of Canada x
6 · The paper itself

Abstract

Rates of pediatric Crohn's disease (CD) and ulcerative colitis (UC) are increasing globally. Differentiation of these inflammatory bowel disease (IBD) subtypes however can be challenging when relying on invasive endoscopic approaches. We sought to identify urinary metabolic signatures of pediatric IBD at diagnosis, and during induction treatment. Nontargeted metabolite profiling of urine samples from CD (

Indexed as

biomarker discoverycapillary electrophoresis-mass spectrometryCrohn’s diseasediagnosisexclusive enteral nutritionmetabolomicspediatric inflammatory bowel diseasetreatment monitoringulcerative colitisurine

Identifiers

PMID33921143
PMCPMC8071482
OpenAlexW3155506143

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.