Evidence map›Paper›PMID 33921209›Full record

ArticleInternational journal of molecular sciences2021

NFAT5 Is Involved in GRP-Enhanced Secretion of GLP-1 by Sodium.

Caini Fan, Laureano D Asico, Van Anthony M Villar, Jessica Hunt, Santiago Cuevas, Ines Armando, Pedro A Jose, Prasad R Konkalmatt

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Caini FanDivision of Renal Diseases & Hypertension, The George Washington University School of Medicine & Health Science, Washington, DC 20052, USA.
Laureano D AsicoDivision of Renal Diseases & Hypertension, The George Washington University School of Medicine & Health Science, Washington, DC 20052, USA.
Van Anthony M VillarDivision of Renal Diseases & Hypertension, The George Washington University School of Medicine & Health Science, Washington, DC 20052, USA.
Jessica HuntDivision of Renal Diseases & Hypertension, The George Washington University School of Medicine & Health Science, Washington, DC 20052, USA.
Santiago CuevasDivision of Renal Diseases & Hypertension, The George Washington University School of Medicine & Health Science, Washington, DC 20052, USA.
Ines ArmandoDivision of Renal Diseases & Hypertension, The George Washington University School of Medicine & Health Science, Washington, DC 20052, USA.
Pedro A JoseDivision of Renal Diseases & Hypertension, The George Washington University School of Medicine & Health Science, Washington, DC 20052, USA.
Prasad R KonkalmattDivision of Renal Diseases & Hypertension, The George Washington University School of Medicine & Health Science, Washington, DC 20052, USA.
George Washington University · US

Funding

Dopamine/Angiostensin Receptors in Genetic HypertensionP01HL074940 · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · 2004 to 2005
$4.0M
RENAL DOPAMINE-1 RECEPTOR DEFECT IN HYPERTENSIONR01DK039308 · GEORGETOWN UNIVERSITY · 1987 to 2004
$1.3M
Lipid rafts, dopamine 1 receptor, and hypertensionR01DK119652 · NIDDK · GEORGE WASHINGTON UNIVERSITY · PI Pedro A. Jose · 2022 to 2023
$1.3M
NIH HHS P01HL074940NIH HHS R01DK039308NIH HHS R01DK119652NIH HHS R01HL092196NIH HHS R37HL023081NIH HHS R56DK116828Overseas Research and Training Project of Talents of Henan Provincial Department of Health 2018103
6 · The paper itself

Abstract

Gastrin, secreted by G-cells, and glucagon-like peptide-1 (GLP-1), secreted by L-cells, may participate in the regulation of sodium balance. We studied the effect of sodium in mice in vivo and mouse ileum and human L-cells, on GLP-1 secretion, and the role of NFAT5 and gastrin-releasing peptide receptor (GRPR) in this process. A high-sodium diet increases serum GLP-1 levels in mice. Increasing sodium concentration stimulates GLP-1 secretion from mouse ileum and L-cells. GRP enhances the high sodium-induced increase in GLP-1 secretion. High sodium increases cellular GLP-1 expression, while low and high sodium concentrations increase NFAT5 and GRPR expression. Silencing NFAT5 in L-cells abrogates the stimulatory effect of GRP on the high sodium-induced GLP-1 secretion and protein expression, and the sodium-induced increase in GRPR expression. GLP-1 and gastrin decrease the expression of Na

Indexed as

AnimalsGastrinsGastrin-Secreting CellsGene Expression RegulationGene SilencingGlucagon-Like Peptide 1Glucagon-Like Peptide-1 ReceptorHumansHypertensionKidney Tubules, ProximalMicePhosphorylationSodiumSodium-Hydrogen Exchanger 3Sodium-Potassium-Exchanging ATPaseTranscription FactorsGastrinsGlucagon-Like Peptide 1Glucagon-Like Peptide-1 ReceptorNFAT5 protein, humanSLC9A3 protein, humanSodiumSodium-Hydrogen Exchanger 3Sodium-Potassium-Exchanging ATPaseTranscription Factorsgastringastrin-releasing peptideglucagon-like peptide-1NFAT5

Identifiers

PMID33921209
PMCPMC8069329
OpenAlexW3153641398

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.