Evidence map›Paper›PMID 33921816›Full record

ReviewInternational journal of molecular sciences2021

An Overview of Long Non-Coding (lnc)RNAs in Neuroblastoma.

Francesca Baldini, Matilde Calderoni, Laura Vergani, Paola Modesto, Tullio Florio, Aldo Pagano

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Molecular Determinants of Neuroblastoma.International journal of molecular sciences · 2022
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Francesca BaldiniDepartment of Experimental Medicine, University of Genova, 16132 Genova, Italy.ORCID 0000-0002-6284-436X
Matilde CalderoniDepartment of Experimental Medicine, University of Genova, 16132 Genova, Italy.ORCID 0000-0001-9526-1673
Laura VerganiDepartment of Earth, Environment and Life Sciences DISTAV, University of Genova, 16132 Genova, Italy.
Paola ModestoNational Reference Center for Veterinary and Comparative Oncology-Veterinary Medical Research Institute for Piemonte, Liguria and Valle d'Aosta, 10154 Torino, Italy.ORCID 0000-0002-8865-2366
Tullio FlorioIRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy.ORCID 0000-0002-2394-996X
Aldo PaganoDepartment of Experimental Medicine, University of Genova, 16132 Genova, Italy.ORCID 0000-0001-8035-9299
University of Genoa · ITOspedale Policlinico San Martino · ITIstituto Zooprofilattico Sperimentale del Piemonte Liguria e Valle d'Aosta · IT

Funding

Associazione Italiana per la Lotta al Neuroblastoma ND
6 · The paper itself

Abstract

Neuroblastoma (NB) is a heterogeneous developmental tumor occurring in childhood, which arises from the embryonic sympathoadrenal cells of the neural crest. Although the recent progress that has been done on this tumor, the mechanisms involved in NB are still partially unknown. Despite some genetic aberrations having been identified, the sporadic cases represent the majority. Due to its wide heterogeneity in clinical behavior and etiology, NB represents a challenge in terms of prevention and treatment. Since a definitive therapy is lacking so far, there is an urgent necessity to unveil the molecular mechanisms behind NB onset and progression to develop new therapeutic approaches. Long non-coding RNAs (lncRNAs) are a group of RNAs longer than 200 nucleotides. Whether lncRNAs are destined to become a protein or not, they exert multiple biological functions such as regulating gene expression and functions. In recent decades, different research has highlighted the possible role of lncRNAs in the pathogenesis of many diseases, including cancer. Moreover, lncRNAs may represent potential markers or targets for diagnosis and treatment of diseases. This mini-review aimed to briefly summarize the most recent findings on the involvement of some lncRNAs in NB disease by focusing on their mechanisms of action and possible role in unveiling NB onset and progression.

Indexed as

AnimalsGene Expression Regulation, NeoplasticHumansNeuroblastomaRNA, Long NoncodingRNA, Long NoncodingcancerlncRNAsneuroblastoma

Identifiers

PMID33921816
PMCPMC8072620
OpenAlexW3156047723

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.