Evidence map›Paper›PMID 33921980›Full record

ArticleNutrients2021

Postnatal Iron Supplementation with Ferrous Sulfate vs. Ferrous Bis-Glycinate Chelate: Effects on Iron Metabolism, Growth, and Central Nervous System Development in Sprague Dawley Rat Pups.

Shasta McMillen, Bo Lönnerdal

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Shasta McMillenDepartment of Nutrition, University of California, Davis, CA 95616, USA.ORCID 0000-0001-7373-3844
Bo LönnerdalDepartment of Nutrition, University of California, Davis, CA 95616, USA.
University of California, Davis · US

Funding

Albion Minerals and Balchem Corporation A18-2211
6 · The paper itself

Abstract

Iron-fortified formulas and iron drops (both usually ferrous sulfate, FS) prevent early life iron deficiency, but may delay growth and adversely affect neurodevelopment by providing excess iron. We used a rat pup model to investigate iron status, growth, and development outcomes following daily iron supplementation (10 mg iron/kg body weight, representative of iron-fortified formula levels) with FS or an alternative, bioavailable form of iron, ferrous bis-glycinate chelate (FC). On postnatal day (PD) 2, sex-matched rat litters (

Indexed as

Dietary SupplementsAnimalsAnimals, NewbornCentral Nervous SystemFerrous CompoundsGene Expression RegulationGlycineHippocampusHomeostasisIronIron Chelating AgentsMyelin SheathOxidative StressRatsRats, Sprague-DawleyTrace Elementsferrous bisglycinateFerrous Compoundsferrous sulfateGlycineIronIron Chelating AgentsTrace Elementsbrainferrous bis-glycinateferrous sulfateinfant nutritioniron supplementation

Identifiers

PMID33921980
PMCPMC8143548
OpenAlexW3154229969

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.