Evidence map›Paper›PMID 33922066›Full record

ReviewNanomaterials (Basel, Switzerland)2021

Nonviral Locally Injected Magnetic Vectors for In Vivo Gene Delivery: A Review of Studies on Magnetofection.

Artem A Sizikov, Marianna V Kharlamova, Maxim P Nikitin, Petr I Nikitin, Eugene L Kolychev

Open access · goldAbstract readReview
In one paragraph

Review in Nanomaterials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Artem A SizikovMoscow Institute of Physics and Technology, 141701 Dolgoprudny, Russia.
Marianna V KharlamovaMoscow Institute of Physics and Technology, 141701 Dolgoprudny, Russia.ORCID 0000-0003-1029-7138
Maxim P NikitinMoscow Institute of Physics and Technology, 141701 Dolgoprudny, Russia.
Petr I NikitinProkhorov General Physics Institute of the Russian Academy of Sciences, 117942 Moscow, Russia.ORCID 0000-0003-1573-5512
Eugene L KolychevMoscow Institute of Physics and Technology, 141701 Dolgoprudny, Russia.ORCID 0000-0002-8420-5067
Moscow Institute of Physics and Technology · RUProkhorov General Physics Institute · RU

Funding

Ministry of Science and Higher Education of the Russian Federation agreement # 075-03-2021-095, project 0714-2020-0004 (sections 1, 2.1)Russian Foundation for Basic Research 20-04-60552 (section 2.0), 18-29-09169 (section 2.3)Russian Science Foundation 18-73-10102 (sections 2.2, 3)
6 · The paper itself

Abstract

Magnetic nanoparticles have been widely used in nanobiomedicine for diagnostics and the treatment of diseases, and as carriers for various drugs. The unique magnetic properties of "magnetic" drugs allow their delivery in a targeted tumor or tissue upon application of a magnetic field. The approach of combining magnetic drug targeting and gene delivery is called magnetofection, and it is very promising. This method is simple and efficient for the delivery of genetic material to cells using magnetic nanoparticles controlled by an external magnetic field. However, magnetofection in vivo has been studied insufficiently both for local and systemic routes of magnetic vector injection, and the relevant data available in the literature are often merely descriptive and contradictory. In this review, we collected and systematized the data on the efficiency of the local injections of magnetic nanoparticles that carry genetic information upon application of external magnetic fields. We also investigated the efficiency of magnetofection in vivo, depending on the structure and coverage of magnetic vectors. The perspectives of the development of the method were also considered.

Indexed as

gene deliverymagnetic nanoparticlesmagnetofection

Identifiers

PMID33922066
PMCPMC8143545
OpenAlexW3159839668

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.