Evidence map›Paper›PMID 33922522›Full record

ArticlePharmaceuticals (Basel, Switzerland)2021

Effect of Dihydroartemisinin-Piperaquine on the Pharmacokinetics of Praziquantel for Treatment of

Omary Mashiku Minzi, Rajabu Hussein Mnkugwe, Eliford Ngaimisi, Safari Kinung'hi, Anna Hansson, Anton Pohanka, Appolinary Kamuhabwa, Eleni Aklillu

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.0field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Efficacy of Single-Dose Praziquantel for the Treatment ofPathogens (Basel, Switzerland) · 2023
    Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Omary Mashiku MinziDepartment of Clinical Pharmacy and Pharmacology, School of Pharmacy, Muhimbili University of Health and Allied Sciences, 11103 Dar es Salaam, Tanzania.
Rajabu Hussein MnkugweDivision of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, 141 86 Stockholm, Sweden.ORCID 0000-0002-0746-3169
Eliford NgaimisiOffice of Clinical Pharmacology, Division of Pharmacometrics, Food and Drugs Administration, Silver Spring, MD 20993, USA.ORCID 0000-0001-7096-5279
Safari Kinung'hiNational Institute for Medical Research, Mwanza Research Centre, 33104 Mwanza, Tanzania.
Anna HanssonDepartment of Clinical Pharmacology, Karolinska University Hospital-Huddinge, 141 86 Stockholm, Sweden.
Anton PohankaDivision of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, 141 86 Stockholm, Sweden.
Appolinary KamuhabwaDepartment of Clinical Pharmacy and Pharmacology, School of Pharmacy, Muhimbili University of Health and Allied Sciences, 11103 Dar es Salaam, Tanzania.
Eleni AklilluDivision of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, 141 86 Stockholm, Sweden.ORCID 0000-0002-9788-0790
Muhimbili University of Health and Allied Sciences · TZKarolinska University Hospital · SEKarolinska Institutet · SENational Institute for Medical Research · TZUnited States Food and Drug Administration · US

Funding

Swedish International Development Agency (Sida) 51170072
6 · The paper itself

Abstract

Praziquantel (PZQ) and dihydroartemisinin-piperaquine (DHP) combination recently showed superior effectiveness than PZQ alone to treat intestinal schistosomiasis. In this follow-up study, we investigated the effect of DHP co-administration on the pharmacokinetics of PZQ and its enantiomers among 64

Indexed as

dihydroartemisinin-piperaquinepraziquantelpraziquantel enantiomers pharmacokinetics interactionSchistosoma mansoni

Identifiers

PMID33922522
PMCPMC8145331
OpenAlexW3157714408

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.