Evidence map›Paper›PMID 33923162›Full record

ArticleBiomolecules2021

S100P Interacts with p53 while Pentamidine Inhibits This Interaction.

Revansiddha H Katte, Deepu Dowarha, Ruey-Hwang Chou, Chin Yu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. TetronicPharmaceutics · 2026
    Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Revansiddha H KatteDepartment of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan.ORCID 0000-0002-3844-8797
Deepu DowarhaDepartment of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan.ORCID 0000-0001-9986-368X
Ruey-Hwang ChouGraduate Institute of Biomedical Sciences and Center for Molecular Medicine, China Medical University, Taichung 40402, Taiwan.ORCID 0000-0002-2297-2180
Chin YuDepartment of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan.
National Tsing Hua University · TWAsia University · TW

Funding

China Medical University, Drug Development Center, Taichung, Taiwan CMU108-MF-49Ministry of Science and Technology, Taiwan 108-2320-B039-013Ministry of Science and Technology, Taiwan MOST107B3079I5
6 · The paper itself

Abstract

S100P, a small calcium-binding protein, associates with the p53 protein with micromolar affinity. It has been hypothesized that the oncogenic function of S100P may involve binding-induced inactivation of p53. We used

Indexed as

Binding SitesCalcium-Binding ProteinsCell Line, TumorCell ProliferationHumansModels, MolecularNeoplasm ProteinsPentamidineProtein BindingProtein DomainsProtein Interaction MappingS100 ProteinsTumor Suppressor Protein p53Calcium-Binding ProteinsNeoplasm ProteinsPentamidineS100P protein, humanS100 ProteinsTP53 protein, humanTumor Suppressor Protein p531H-5N HSQC spectrumbiomolecular dockingHADDOCK programp53-TAD (73 amino acids)protein-protein interactionsS100P

Identifiers

PMID33923162
PMCPMC8145327
OpenAlexW3159942885

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.