Evidence map›Paper›PMID 33924212›Full record

ArticleMolecules (Basel, Switzerland)2021

Proteomic and Bioinformatic Investigation of Altered Pathways in Neuroglobin-Deficient Breast Cancer Cells.

Michele Costanzo, Marco Fiocchetti, Paolo Ascenzi, Maria Marino, Marianna Caterino, Margherita Ruoppolo

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Proteomics and Metabolomics in Biomedicine.International journal of molecular sciences · 2023
    Article
  8. Expression ofMolecular therapy. Nucleic acids · 2023
    Article
  9. Article
  10. Deciphering the Relationship between SARS-CoV-2 and Cancer.International journal of molecular sciences · 2023
    Review
  11. Review
  12. Article
  13. Sex-Gender-Based Differences in Metabolic Diseases.Handbook of experimental pharmacology · 2023
    Review
  14. Article
  15. Sex differences in the human metabolome.Biology of sex differences · 2022
    Review
  16. Article
  17. Article
  18. COVIDomics: The Proteomic and Metabolomic Signatures of COVID-19.International journal of molecular sciences · 2022
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Michele CostanzoDepartment of Molecular Medicine and Medical Biotechnology, School of Medicine, University of Naples Federico II, 80131 Naples, Italy.ORCID 0000-0002-6386-2009
Marco FiocchettiDepartment of Science, University Roma Tre, 00146 Rome, Italy.ORCID 0000-0002-4888-0567
Paolo AscenziDepartment of Science, University Roma Tre, 00146 Rome, Italy.
Maria MarinoDepartment of Science, University Roma Tre, 00146 Rome, Italy.ORCID 0000-0002-6314-3397
Marianna CaterinoDepartment of Molecular Medicine and Medical Biotechnology, School of Medicine, University of Naples Federico II, 80131 Naples, Italy.ORCID 0000-0001-6035-8213
Margherita RuoppoloDepartment of Molecular Medicine and Medical Biotechnology, School of Medicine, University of Naples Federico II, 80131 Naples, Italy.ORCID 0000-0002-7364-0602
Ceinge Biotecnologie Avanzate (Italy) · ITRoma Tre University · IT

Funding

Ministero dell'Istruzione, dell'Università e della Ricerca PRIN 2017SNRXH3
6 · The paper itself

Abstract

Neuroglobin (NGB) is a myoglobin-like monomeric globin that is involved in several processes, displaying a pivotal redox-dependent protective role in neuronal and extra-neuronal cells. NGB remarkably exerts its function upon upregulation by NGB inducers, such as 17β-estradiol (E2) and H

Indexed as

ProteomicsApoptosisBreast NeoplasmsComputational BiologyEstrogen Receptor alphaFemaleGene Expression Regulation, NeoplasticGene Knockout TechniquesHumansMCF-7 CellsNeoplasm ProteinsNeuroglobinOxidative StressEstrogen Receptor alphaNeoplasm ProteinsNeuroglobin17β-estradiolapoptosisbioinformaticsbreast cancer cellslabel-free proteomicsmitochondrianeuroglobinoxidative stresspathway analysis

Identifiers

PMID33924212
PMCPMC8074618
OpenAlexW3154605209

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.