Evidence map›Paper›PMID 33924409›Full record

ArticleViruses2021

Molecular Characterization and Seroprevalence of Hepatitis E Virus in Inflammatory Bowel Disease Patients and Solid Organ Transplant Recipients.

Juozas Grigas, Maria Montoya, Evelina Simkute, Marius Buitkus, Ruta Zagrabskaite, Arnoldas Pautienius, Dainius Razukevicius, Laimas Virginijus Jonaitis, Gediminas Kiudelis, Jurgita Skieceviciene and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Review
  4. Article
  5. Hepatitis E Virus Prevalence and Associated Risk Factors in High-Risk Groups: A Cross-Sectional Study.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2022
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Juozas GrigasLaboratory of Immunology, Department of Anatomy and Physiology, Lithuanian University of Health Sciences, Tilzes Str. 18, LT-47181 Kaunas, Lithuania.ORCID 0000-0003-2450-5700
Maria MontoyaCentro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Cientificas (CIB-CSIC), Calle Ramiro de Maeztu, 9, 28040 Madrid, Spain.ORCID 0000-0002-5703-7360
Evelina SimkuteLaboratory of Immunology, Department of Anatomy and Physiology, Lithuanian University of Health Sciences, Tilzes Str. 18, LT-47181 Kaunas, Lithuania.
Marius BuitkusInstitute of Clinical Medicine, Vilnius University, M. K. Ciurlionio Str. 21/27, LT-03101 Vilnius, Lithuania.
Ruta ZagrabskaiteSerology Unit, National Food and Veterinary Risk Assessment Institute, J. Kairiukscio Str. 10, LT-08409 Vilnius, Lithuania.
Arnoldas PautieniusLaboratory of Immunology, Department of Anatomy and Physiology, Lithuanian University of Health Sciences, Tilzes Str. 18, LT-47181 Kaunas, Lithuania.ORCID 0000-0002-4494-2724
Dainius RazukeviciusDepartment of Maxillofacial Surgery, Faculty of Odontology, Lithuanian University of Health Sciences, A. Mickeviciaus Str. 9, LT-44307 Kaunas, Lithuania.
Laimas Virginijus JonaitisDepartment of Gastroenterology, Faculty of Medicine, Lithuanian University of Health Sciences, Eiveniu Str. 2, LT-50161 Kaunas, Lithuania.ORCID 0000-0001-9086-3675
Gediminas KiudelisDepartment of Gastroenterology, Faculty of Medicine, Lithuanian University of Health Sciences, Eiveniu Str. 2, LT-50161 Kaunas, Lithuania.
Jurgita SkiecevicieneDepartment of Gastroenterology, Faculty of Medicine, Lithuanian University of Health Sciences, Eiveniu Str. 2, LT-50161 Kaunas, Lithuania.ORCID 0000-0002-4893-6612
Ruta VaiciunieneDepartment of Nephrology, Faculty of Medicine, Lithuanian University of Health Sciences, Eiveniu Str. 2, LT-50161 Kaunas, Lithuania.ORCID 0000-0002-1595-8612
Asta StankuvieneDepartment of Nephrology, Faculty of Medicine, Lithuanian University of Health Sciences, Eiveniu Str. 2, LT-50161 Kaunas, Lithuania.
Inga Arune BumblyteDepartment of Nephrology, Faculty of Medicine, Lithuanian University of Health Sciences, Eiveniu Str. 2, LT-50161 Kaunas, Lithuania.
Juozas KupcinskasDepartment of Gastroenterology, Faculty of Medicine, Lithuanian University of Health Sciences, Eiveniu Str. 2, LT-50161 Kaunas, Lithuania.ORCID 0000-0002-8760-7416
Arunas StankeviciusLaboratory of Immunology, Department of Anatomy and Physiology, Lithuanian University of Health Sciences, Tilzes Str. 18, LT-47181 Kaunas, Lithuania.
Lithuanian University of Health Sciences · LTConsejo Superior de Investigaciones Científicas · ESVilnius University · LT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Seroprevalence rates and molecular characterization of hepatitis E virus (HEV) prevalent in the Lithuanian human population has not yet been evaluated. Immunosuppressed individuals have been recognized as a risk group for chronic hepatitis due to HEV genotype 3 (HEV-3) infections. The objectives of the present study were to determine prevalence rates of anti-HEV antibodies among inflammatory bowel disease (IBD) patients and solid organ transplant (SOT) recipients, to isolate and characterize HEV strain present in the Lithuanian human population, and to investigate its capacity to infect non-human primate (MARC-145 and Vero), swine (PK-15) and murine (Neuro-2a) cells in vitro. In the present study, the significant difference of anti-HEV IgG prevalence between healthy (3.0% (95% CI 0-6.3)) and immunosuppressed individuals (12.0% [95% CI 8.1-15.9]) was described. Moreover, our findings showed that anti-HEV IgG seropositivity can be significantly predicted by increasing age (OR = 1.032,

Indexed as

AdolescentAdultAgedAged, 80 and overAnimalsCell LineFemaleHaplorhiniHepatitis EHepatitis E virusHumansImmunocompromised HostInflammatory Bowel DiseasesLithuaniaMaleMicebiological therapyCrohn’s diseasegenotype 3hepatitis Eimmunosuppressioninflammatory bowel diseaseMARC-145solid organ transplantulcerative colitiszoonosis

Identifiers

PMID33924409
PMCPMC8070591
OpenAlexW3153265113

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.