Evidence map›Paper›PMID 33924575›Full record

ArticleInternational journal of molecular sciences2021

Pathophysiological In Vitro Profile of Neuronal Differentiated Cells Derived from Niemann-Pick Disease Type C2 Patient-Specific iPSCs Carrying the

Maik Liedtke, Christin Völkner, Alexandra V Jürs, Franziska Peter, Michael Rabenstein, Andreas Hermann, Moritz J Frech

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Inborn errors of metabolism: Lessons from iPSC models.Reviews in endocrine & metabolic disorders · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Maik LiedtkeTranslational Neurodegeneration Section "Albrecht Kossel", Department of Neurology, University Medical Center Rostock, 18147 Rostock, Germany.
Christin VölknerTranslational Neurodegeneration Section "Albrecht Kossel", Department of Neurology, University Medical Center Rostock, 18147 Rostock, Germany.
Alexandra V JürsTranslational Neurodegeneration Section "Albrecht Kossel", Department of Neurology, University Medical Center Rostock, 18147 Rostock, Germany.
Franziska PeterTranslational Neurodegeneration Section "Albrecht Kossel", Department of Neurology, University Medical Center Rostock, 18147 Rostock, Germany.
Michael RabensteinTranslational Neurodegeneration Section "Albrecht Kossel", Department of Neurology, University Medical Center Rostock, 18147 Rostock, Germany.ORCID 0000-0001-7712-224X
Andreas HermannTranslational Neurodegeneration Section "Albrecht Kossel", Department of Neurology, University Medical Center Rostock, 18147 Rostock, Germany.ORCID 0000-0002-7364-7791
Moritz J FrechTranslational Neurodegeneration Section "Albrecht Kossel", Department of Neurology, University Medical Center Rostock, 18147 Rostock, Germany.ORCID 0000-0003-2421-8779
University of Rostock · DEGerman Center for Neurodegenerative Diseases · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Niemann-Pick type C2 (NP-C2) disease is a rare hereditary disease caused by mutations in the

Indexed as

Cell DifferentiationAntioxidantsAutophagyCholesterolHEK293 CellsHumansInduced Pluripotent Stem CellsMaleMutationNeurogliaNeuronsNiemann-Pick Disease, Type COxidative StressReactive Oxygen SpeciesVesicular Transport ProteinsAntioxidantsCholesterolNPC2 protein, humanReactive Oxygen SpeciesVesicular Transport ProteinsautophagycholesterolfilipinhiPSCNiemann-Pick type C2 (NP-C2)oxidative stresspatch clamp

Identifiers

PMID33924575
PMCPMC8069078
OpenAlexW3153053683

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.