Evidence map›Paper›PMID 33925440›Full record

ArticleCells2021

Transmembrane and Tetratricopeptide Repeat Containing 4 Is a Novel Diagnostic Marker for Prostate Cancer with High Specificity and Sensitivity.

Rania Makboul, Islam F Abdelkawi, Dalia M Badary, Mahmoud R A Hussein, Johng S Rhim, Eman A Toraih, Mourad Zerfaoui, Zakaria Y Abd Elmageed

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Rania MakboulDepartment of Pathology and Urology, Faculty of Medicine, Assiut University, Assiut 71111, Egypt.
Islam F AbdelkawiDepartment of Urology, Faculty of Medicine, Assiut University, Assiut 71111, Egypt.
Dalia M BadaryDepartment of Pathology and Urology, Faculty of Medicine, Assiut University, Assiut 71111, Egypt.ORCID 0000-0003-0252-7175
Mahmoud R A HusseinDepartment of Pathology and Urology, Faculty of Medicine, Assiut University, Assiut 71111, Egypt.ORCID 0000-0001-9366-2211
Johng S RhimDepartment of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Eman A ToraihDepartment of Surgery, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USA.ORCID 0000-0001-9267-3787
Mourad ZerfaouiDepartment of Surgery, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USA.
Zakaria Y Abd ElmageedDepartment of Pharmacology, Edward Via College of Osteopathic Medicine, University of Louisiana at Monroe, Monroe, LA 71203, USA.ORCID 0000-0003-4031-0348
Assiut University · EGTulane University · USUniformed Services University of the Health Sciences · USUniversity of Louisiana at Monroe · US

Funding

VCOM Research Fund 00
6 · The paper itself

Abstract

The histopathologic diagnosis of prostate cancer (PCa) from biopsies is a current challenge if double or triple staining is needed. Therefore, there is an urgent need for development of a new reliable biomarker to diagnose PCa patients. We aimed to explore and compare the expression of TMTC4 in PCa cells and tissue specimens and evaluate its sensitivity and specificity. The expression of TMTC4 in PCa and normal prostate epithelial cells was determined by real-time PCR and Western blot analyses. Immunohistochemical (IHC) staining of TMTC4 was performed on tissues collected from PCa and benign prostatic hyperplasia (BPH). Our results show a high expression of TMTC4 on mRNA and protein levels in PCa versus BPH1 and normal cells (

Indexed as

Tetratricopeptide RepeatAgedBiomarkers, TumorCell Line, TumorCohort StudiesGene Expression Regulation, NeoplasticHumansMaleMannosyltransferasesMembrane ProteinsProstatic HyperplasiaProstatic NeoplasmsRNA, MessengerSensitivity and SpecificityUp-RegulationBiomarkers, TumorMannosyltransferasesMembrane ProteinsRNA, MessengerTMTC4 protein, humanbiomarkerimmunohistochemical stainingprostatic cancersensitivity and specificityTMTC4

Identifiers

PMID33925440
PMCPMC8146280
OpenAlexW3157223359

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.