Evidence map›Paper›PMID 33925531›Full record

ArticleInternational journal of molecular sciences2021

Plasticity of Naturally Occurring Regulatory T Cells in Allergic Airway Disease Is Modulated by the Transcriptional Activity of

Morgan MacBeth, Anthony Joetham, Erwin W Gelfand, Michaela Schedel

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Editorial of Special Issue "Molecular Mechanisms of Allergy and Asthma".International journal of molecular sciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Morgan MacBethDivision of Allergy and Immunology and Cell Biology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA.
Anthony JoethamDivision of Allergy and Immunology and Cell Biology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA.
Erwin W GelfandDivision of Allergy and Immunology and Cell Biology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA.
Michaela SchedelDivision of Allergy and Immunology and Cell Biology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA.
National Jewish Health · USUniversity of Colorado Denver · US

Funding

Eugene F. and Easton M. Crawford Charitable Lead Unitrust, the Pohs, Siegel, and Dreizzesun Funds xHeisenberg Professorship (German Research Foundation, DFG) Project number 406086772, 1750/1-1Marie Curie International Outgoing Fellowship (European Commission) POIF-GA-2009-236137National Institute of Health AI-77609
6 · The paper itself

Abstract

The impact of naturally occurring regulatory T cells (nTregs) on the suppression or induction of lung allergic responses in mice depends on the nuclear environment and the production of the pro-inflammatory cytokine interleukin 6 (IL-6). These activities were shown to be different in nTregs derived from wild-type (WT) and CD8-deficient mice (CD8

Indexed as

Adaptation, PhysiologicalAnimalsCell PlasticityCytokinesHypersensitivityInterleukin-10Interleukin-6Lung DiseasesMaleMiceMice, Inbred C57BLNF-kappa BPromoter Regions, GeneticT-Lymphocytes, RegulatoryTumor Necrosis Factor-alphaCytokinesInterleukin-10Interleukin-6interleukin-6, mouseNF-kappa BTumor Necrosis Factor-alphaIL-6naturally occurring T regulatory cells (nTregs)plasticitytranscriptional regulationtranscription factor binding

Identifiers

PMID33925531
PMCPMC8123826
OpenAlexW3157578292

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.