Evidence map›Paper›PMID 33925659›Full record

ArticleCells2021

DNMT3B Is an Oxygen-Sensitive De Novo Methylase in Human Mesenchymal Stem Cells.

Fatma Dogan, Rakad M Kh Aljumaily, Mark Kitchen, Nicholas R Forsyth

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Clinical Significance of SOX2 Promoter Methylation in Breast Cancer Prognosis.Cancer control : journal of the Moffitt Cancer Center
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Fatma DoganThe Guy Hilton Research Laboratories, Faculty of Medicine and Health Sciences, School of Pharmacy and Bioengineering, Keele University, Stoke on Trent ST5 5BG, UK.ORCID 0000-0003-0632-3719
Rakad M Kh AljumailyDepartment of Biology, College of Science, University of Baghdad, Baghdad 17635, Iraq.
Mark KitchenThe Guy Hilton Research Laboratories, Faculty of Medicine and Health Sciences, School of Pharmacy and Bioengineering, Keele University, Stoke on Trent ST5 5BG, UK.
Nicholas R ForsythThe Guy Hilton Research Laboratories, Faculty of Medicine and Health Sciences, School of Pharmacy and Bioengineering, Keele University, Stoke on Trent ST5 5BG, UK.ORCID 0000-0001-5156-4824
Keele University · GBUniversity of Baghdad · IQ

Funding

Iraqi Ministry of Higher Education and Scientific Research, University of Baghdad, Baghdad, Iraq
6 · The paper itself

Abstract

The application of physiological oxygen (physoxia) concentrations is becoming increasingly commonplace within a mammalian stem cell culture. Human mesenchymal stem cells (hMSCs) attract widespread interest for clinical application due to their unique immunomodulatory, multi-lineage potential, and regenerative capacities. Descriptions of the impact of physoxia on global DNA methylation patterns in hMSCs and the activity of enzymatic machinery responsible for its regulation remain limited. Human bone marrow-derived mesenchymal stem cells (BM-hMSCs, passage 1) isolated in reduced oxygen conditions displayed an upregulation of SOX2 in reduced oxygen conditions vs. air oxygen (21% O

Indexed as

5-MethylcytosineAdultAirBasic Helix-Loop-Helix ProteinsCell DifferentiationCells, CulturedDNA (Cytosine-5-)-MethyltransferasesDNA MethylationDNA Methyltransferase 3BEndothelial PAS Domain-Containing Protein 1FemaleGene Expression RegulationHumansHypoxia-Inducible Factor 1, alpha SubunitImmunophenotypingMale5-hydroxymethylcytosine5-MethylcytosineBasic Helix-Loop-Helix ProteinsDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3BEndothelial PAS Domain-Containing Protein 1HIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitMixed Function OxygenasesNanog Homeobox ProteinOctamer Transcription Factor-3OxygenPOU5F1 protein, humanProto-Oncogene ProteinsRNA, MessengerSOXB1 Transcription FactorsTET1 protein, humancharacterisationDNA methyltransferaseepigenetichydroxymethylationmesenchymal stem cellsmethylationphysiological oxygen

Identifiers

PMID33925659
PMCPMC8145390
OpenAlexW3158008160

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.