ArticleCirculation research2021
Programming to S1PR1
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Article in Circulation research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 41 citations in OpenAlex.
- Association between the endothelial activation and stress index and 30-day in-hospital mortality rate in patients with traumatic lung injury: a retrospective analysis based on the MIMIC-IV database.Journal of thoracic disease · 2026Article
- SPNS2 exports sphingosine-1-phosphate and imports glucose.Nature communications · 2026Article
- ERG-deficient endothelium identifies IL-8/CXCR2 axis as a therapeutic target for resolving neutrophilic lung vascular injury.JCI insight · 2026Article
- Telomerase-mediated immortalization preserves the anti-inflammatory activity of dental pulp stem cell extracellular vesicles.Frontiers in immunology · 2026Article
- The S1PR1-CCN1 axis drives endothelial-to-mesenchymal transition and vascular instability in brain arteriovenous malformations.European journal of medical research · 2025Article
- Molecular Maestro in the Lung: The Sphingolipid Rheostat.American journal of respiratory cell and molecular biology · 2025Article
- S1PR1-biased activation drives the resolution of endothelial dysfunction-associated inflammatory diseases by maintaining endothelial integrity.Nature communications · 2025Article
- Repeated social defeat in male mice induced unique RNA profiles in projection neurons from the amygdala to the hippocampus.Brain, behavior, & immunity - health · 2025Article
- Repolarization of inflammatory macrophages into reparative stage targeting cannabinoid receptor2: a potential perspective to dampen lung injury/ARDS.Frontiers in pharmacology · 2025Review
- Sphingolipid Metabolism and Signalling Pathways in Heart Failure: From Molecular Mechanism to Therapeutic Potential.Journal of inflammation research · 2025Review
- Zonation and ligand and dose dependence of sphingosine 1-phosphate receptor-1 signalling in blood and lymphatic vasculature.Cardiovascular research · 2024Article
- S1PR1 suppresses lung adenocarcinoma progression through p-STAT1/miR-30c-5 p/FOXA1 pathway.Journal of experimental & clinical cancer research : CR · 2024Article
- FAK regulates tension transmission to the nucleus and endothelial transcriptome independent of kinase activity.Cell reports · 2024Article
- Rewiring Endothelial Sphingolipid Metabolism to Favor S1P Over Ceramide Protects From Coronary Atherosclerosis.Circulation research · 2024Article
- Roles of Macrophages and Endothelial Cells and Their Crosstalk in Acute Lung Injury.Biomedicines · 2024Review
- Neutrophil Extracellular Traps Upregulate p21 and Suppress Cell Cycle Progression to Impair Endothelial Regeneration after Inflammatory Lung Injury.Journal of clinical medicine · 2024Article
- AFrontiers in cardiovascular medicine · 2024Article
- Sphingosine-1-Phosphate Receptor 3 Induces Endothelial Barrier Loss via ADAM10-Mediated Vascular Endothelial-Cadherin Cleavage.International journal of molecular sciences · 2023Article
- Common mechanisms underlying diabetic vascular complications: focus on the interaction of metabolic disorders, immuno-inflammation, and endothelial dysfunction.Cell communication and signaling : CCS · 2023Review
- Abnormal Lymphatic Sphingosine-1-Phosphate Signaling Aggravates Lymphatic Dysfunction and Tissue Inflammation.Circulation · 2023Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Md Zahid AkhterPharmacology and Regenerative Medicine and Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago (M.Z.A., J.C.J., V.A.B.R., A.B.M., D.M.).
Jagdish Chandra JoshiPharmacology and Regenerative Medicine and Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago (M.Z.A., J.C.J., V.A.B.R., A.B.M., D.M.).
Vijay Avin Balaji RagunathraoPharmacology and Regenerative Medicine and Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago (M.Z.A., J.C.J., V.A.B.R., A.B.M., D.M.).
Mark Maienschein-ClineResearch Informatics Core, University of Illinois, Chicago (M.M.-C.).
Richard L ProiaGenetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD (R.L.P.).
Asrar B MalikPharmacology and Regenerative Medicine and Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago (M.Z.A., J.C.J., V.A.B.R., A.B.M., D.M.).
Dolly MehtaPharmacology and Regenerative Medicine and Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago (M.Z.A., J.C.J., V.A.B.R., A.B.M., D.M.).
University of Illinois Chicago · USCalifornia Institute for Regenerative Medicine · USIllinois College · USNational Institute of Diabetes and Digestive and Kidney Diseases · US
Funding
TRPC6 Regulation of Lung Endothelial Barrier FunctionP01HL060678 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MALIK, ASRAR B. · 2000 to 2020
$40.1MStrengthening Stakeholder Engagement in Human Research Protections.UL1TR002003 · NCATS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KARNIK, NIRANJAN SUBHASH, MERMELSTEIN, ROBIN J. · 2016 to 2024
$33.7MMouse Models of Novel Sphingolipid Biology and Disease MechanismsZIADK056014 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI PROIA, RICHARD · 2009 to 2025
$10.6MSphingolipid Biology of Inflammation and ImmunityZIADK056015 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI PROIA, RICHARD · 2009 to 2021
$7.9MFocal Adhesion Kinase Regulation of Lung Vascular Permeability and EdemagenesisR01HL084153 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MEHTA, DOLLY · 2007 to 2022
$5.4MMechanisms of endothelial regeneration and resolution of lung vascular injuryR01HL137169 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MEHTA, DOLLY · 2017 to 2020
$2.1MNCATS NIH HHS UL1 TR002003NHLBI NIH HHS P01 HL060678NHLBI NIH HHS R01 HL084153NHLBI NIH HHS R01 HL137169
Abstract
[Figure: see text].
Indexed as
Cell ProliferationRegenerationAcute Lung InjuryAnimalsAnion Transport ProteinsCapillary PermeabilityCell LineageCells, CulturedDisease Models, AnimalEndothelial CellsEndotoxemiaGreen Fluorescent ProteinsHumansLungLysophospholipidsMiceAnion Transport ProteinsGreen Fluorescent ProteinsLysophospholipidsPhosphotransferases (Alcohol Group Acceptor)S1PR1 protein, humanS1pr1 protein, mouseSphingosinesphingosine 1-phosphateSphingosine-1-Phosphate ReceptorsSphingosine KinaseSphk1 protein, mouseSpns2 protein, mouseStat3 protein, mouseSTAT3 Transcription Factoracute lung injuryendothelial cellspermeability
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What Socratic holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.