Evidence map›Paper›PMID 33928089›Full record

ArticleFrontiers in cell and developmental biology2021

BMI1 Drives Steroidogenesis Through Epigenetically Repressing the p38 MAPK Pathway.

Jun Yu, Yibo Wu, Hong Li, Hui Zhou, Cong Shen, Tingting Gao, Meng Lin, Xiuliang Dai, Jian Ou, Meiling Liu and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
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  7. CXCL14 regulates ovarian endometriosis progression by targeting PCNA.American journal of translational research · 2025
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  19. Long non-coding RNAThe Journal of international medical research · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

Jun YuInstitute of Reproductive Medicine, School of Medicine, Nantong University, Nantong, China.
Yibo WuHuman Reproductive and Genetic Center, Affiliated Hospital of Jiangnan University, Wuxi, China.
Hong LiState Key Laboratory of Reproductive Medicine, Center for Reproduction and Genetics, Suzhou Municipal Hospital, The Affiliated Suzhou Hospital of Nanjing Medical University, Gusu School, Nanjing Medical University, Suzhou, China.
Hui ZhouHuman Reproductive and Genetic Center, Affiliated Hospital of Jiangnan University, Wuxi, China.
Cong ShenState Key Laboratory of Reproductive Medicine, Center for Reproduction and Genetics, Suzhou Municipal Hospital, The Affiliated Suzhou Hospital of Nanjing Medical University, Gusu School, Nanjing Medical University, Suzhou, China.
Tingting GaoCenter of Clinical Reproductive Medicine, The Affiliated Changzhou Maternity and Child Health Care Hospital of Nanjing Medical University, Changzhou, China.
Meng LinState Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, Nanjing, China.
Xiuliang DaiCenter of Clinical Reproductive Medicine, The Affiliated Changzhou Maternity and Child Health Care Hospital of Nanjing Medical University, Changzhou, China.
Jian OuState Key Laboratory of Reproductive Medicine, Center for Reproduction and Genetics, Suzhou Municipal Hospital, The Affiliated Suzhou Hospital of Nanjing Medical University, Gusu School, Nanjing Medical University, Suzhou, China.
Meiling LiuNational Health Commission Key Laboratory of Male Reproductive Health, National Research Institute for Family Planning, Beijing, China.
Xiaoyan HuangState Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, Nanjing, China.
Bo ZhengState Key Laboratory of Reproductive Medicine, Center for Reproduction and Genetics, Suzhou Municipal Hospital, The Affiliated Suzhou Hospital of Nanjing Medical University, Gusu School, Nanjing Medical University, Suzhou, China.
Fei SunInstitute of Reproductive Medicine, School of Medicine, Nantong University, Nantong, China.
Nanjing Medical University · CNJiangnan University · CNNanjing Maternity and Child Health Care Hospital · CNNantong University · CNSuzhou Municipal Hospital · CNNational Health and Family Planning Commission · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Testosterone biosynthesis progressively decreases in aging males primarily as a result of functional changes to Leydig cells. Despite this, the mechanisms underlying steroidogenesis remain largely unclear. Using gene knock-out approaches, we and others have recently identified

Indexed as

Bmi1epigenetic mechanismp38 mitogen-activated protein kinase (MAPK) signalingsteroidogenesistestosterone

Identifiers

PMID33928089
PMCPMC8076678
OpenAlexW3154284061

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.