ReviewESC heart failure2021
Iron deficiency in heart failure.
Review in ESC heart failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it, 90 citations in OpenAlex.
- Impact of Intravenous Iron in patients with heart failure and Iron Deficiency: an updated Meta-analysis of Randomized controlled trials.BMC cardiovascular disorders · 2024Pooled it
- Effect of ferric citrate hydrate on fibroblast growth factor 23 and platelets in non-dialysis-dependent chronic kidney disease and non-chronic kidney disease patients with iron deficiency anemia.Clinical and experimental nephrology · 2024Trial
- Impact of Iron Supplementation on Clinical Outcomes in Iron-Deficient Heart Failure Patients: A Retrospective Cohort Study in Oman.Journal of clinical medicine · 2026Article
- Iron Deficiency Screening in Patients Admitted with Acute Heart Failure Decompensation.Journal of cardiovascular translational research · 2026Article
- Position paper ANMCO in collaboration with Italian Alliance for Cardiovascular Rehabilitation and Prevention (ITACARE-P): 'the management of hospital discharge'.European heart journal supplements : journal of the European Society of Cardiology · 2026Article
- A non-linear pattern of exercise capacity in heart failure across ejection fraction categories.Scientific reports · 2026Article
- Iron deficiency and nutritional status in heart failure with reduced ejection fraction: a cross-sectional study.Cardiology journal · 2026Article
- [Perioperative management of anesthesia in heart failure].Die Anaesthesiologie · 2025Review
- Impact of iron deficiency on health-related quality of life and functional status in adults with chronic heart failure in Nigeria.BMC cardiovascular disorders · 2025Article
- Improving nutrition in pediatric heart failure.JHLT open · 2025Review
- Immunometabolism in heart failure.Nature reviews. Cardiology · 2025Review
- Iron Deficiency in Heart Failure: From ESC Guidelines to Clinical Practice at a Romanian Hospital.Biomedicines · 2025Article
- Effect of Iron Deficiency on Right Ventricular Strain in Patients Diagnosed with Acute Heart Failure.Journal of clinical medicine · 2025Article
- Prevalence of iron deficiency in acute and chronic heart failure according to different clinical definitions.ESC heart failure · 2025Article
- Iron Deficiency Treatment in Heart Failure-Challenges and Therapeutic Solutions.Journal of clinical medicine · 2025Review
- The impact of anemia on left ventricular function and deformation in patients with essential hypertension: a cardiac magnetic resonance study.Quantitative imaging in medicine and surgery · 2025Article
- Iron Deficiency and All-Cause Hospitalization Risk in a Clinical Cohort of COPD.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2025Article
- Machine learning enhanced acute heart failure phenotype prediction using natural language processing and random forest.Frontiers in artificial intelligence · 2025Article
- The Intersection of Heart Failure and Iron Deficiency Anemia: Diagnostic and Therapeutic Approaches.Current cardiology reviews · 2025Review
- Heart failure with reduced ejection fraction and chronic kidney disease: a focus on therapies and interventions.Heart failure reviews · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Iron deficiency is a major heart failure co-morbidity present in about 50% of patients with stable heart failure irrespective of the left ventricular function. Along with compromise of daily activities, it also increases patient morbidity and mortality, which is independent of anaemia. Several trials have established parenteral iron supplementation as an important complimentary therapy to improve patient well-being and physical performance. Intravenous iron preparations, in the first-line ferric carboxymaltose, demonstrated in previous clinical trials superior clinical effect in comparison with oral iron preparations, improving New York Heart Association functional class, 6 min walk test distance, peak oxygen consumption, and quality of life in patients with chronic heart failure. Beneficial effect of iron deficiency treatment on morbidity and mortality of heart failure patients is waiting for conformation in ongoing trials. Although the current guidelines for treatment of chronic and acute heart failure acknowledge importance of iron deficiency correction and recommend intravenous iron supplementation for its treatment, iron deficiency remains frequently undertreated and insufficiently diagnosed in setting of the chronic heart failure. This paper highlights the current state of the art in the pathophysiology of iron deficiency, associations with heart failure trajectory and outcome, and an overview of current guideline-suggested treatment options.
Indexed as
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.