Evidence map›Paper›PMID 33934921›Full record

ArticleEuropean neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology2021

Refining biomarker evaluation in ASD.

James C McPartland

Abstract read
In one paragraph

Article in European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Observational
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

James C McPartlandProfessor of Child Psychiatry and Psychology, Yale Child Study Center, 230 South Frontage Road, New Haven, CT 06520, United States. Electronic address: james.mcpartland@yale.edu.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
The Autism Biomarkers Consortium for Clinical TrialsU19MH108206 · NIMH · YALE UNIVERSITY · PI DZIURA, JAMES DAVID · 2015 to 2024
$68.8M
Biomarker Qualification Plan Development for the N170 in Autism Spectrum DisorderU01FD006888 · FDA · YALE UNIVERSITY · PI MCPARTLAND, JAMES CHARLES · 2019 to 2019
$250k
Biomarker Qualification Plan Development for the Oculomotor Index of Gaze to Human FacesU01FD007000 · FDA · YALE UNIVERSITY · PI MCPARTLAND, JAMES CHARLES · 2020 to 2020
$249k
FDA HHS U01 FD006888FDA HHS U01 FD007000NCATS NIH HHS UL1 TR001863NIMH NIH HHS U19 MH108206
6 · The paper itself

Abstract

This commentary reflects on reasonable biomarker expectations in ASD by addressing three key questions: What is a biomarker? What is required for a biomarker in ASD? How can biomarkers be useful in ASD? In addressing these queries, a path forward emerges based on clear definition of the objective for any given ASD biomarker and evaluation of each biomarker relative to current best practices.

Indexed as

Autism Spectrum DisorderBiomarkersHumansBiomarkersAutism spectrum disorderBiomarkersClinical trialsEndpoints

Identifiers

PMID33934921
PMCPMC8238819

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.