ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2021
Association of Life's Simple 7 with incident dementia and its modification by the apolipoprotein E genotype.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Modifiable lifestyle factors and cognitive reserve: A systematic review of current evidence.Ageing research reviews · 2022Pooled it
- Article
- Plasma phosphorylated tau 181, vascular risk factors, and cognition in elderly Hispanics.Journal of Alzheimer's disease : JAD · 2026Article
- The Role of Posttraumatic Stress Disorder as a Risk Factor for Dementia: A Meta-Analysis.Journal of geriatric psychiatry and neurology · 2026Review
- Additive Effects of White Matter Hyperintensity and APOE ε4 Status on Risk of Incident Dementia in Two Large Longitudinal Cohorts.Annals of neurology · 2026Article
- Gender-dependent association between cardiovascular health and cognitive function in chinese older adults: a community based cohort study.Cerebral circulation - cognition and behavior · 2026Article
- Impact of mid-life cardiovascular health on cognitive change in a bi-ethnic cohort.medRxiv : the preprint server for health sciences · 2025Article
- Life's Essential 8 and midlife trajectories in cognition and brain health: The CARDIA study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Genetic and Lifestyle Risks for Coronary Artery Disease and Long-Term Risk of Incident Dementia Subtypes.Circulation · 2025Article
- Vascular risk factor associations with subjective cognitive decline and mild behavioural impairment.Brain communications · 2025Article
- Dementia risk scores, apolipoprotein E, and risk of Alzheimer's disease: One size does not fit all.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Better cardiovascular health is associated with slowed clinical progression in autosomal dominant frontotemporal lobar degeneration variant carriers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Dementia Risk Scores,medRxiv : the preprint server for health sciences · 2024Article
- Association of Cardiovascular Health With Brain Age Estimated Using Machine Learning Methods in Middle-Aged and Older Adults.Neurology · 2024Article
- Plasma proteomic biomarkers and the association between poor cardiovascular health and incident dementia: The UK Biobank study.Brain, behavior, and immunity · 2024Article
- Epigenetic Age Mediates the Association of Life's Essential 8 With Cardiovascular Disease and Mortality.Journal of the American Heart Association · 2024Article
- Mid-to-Late Life Healthy Lifestyle Modifies Genetic Risk for Longitudinal Cognitive Aging among Asymptomatic Individuals.medRxiv : the preprint server for health sciences · 2024Article
- Risk of Alzheimer's disease is associated with longitudinal changes in plasma biomarkers in the multi-ethnic Washington Heights-Hamilton Heights-Inwood Columbia Aging Project (WHICAP) cohort.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Association between Life's Essential 8 and cognitive function: insights from NHANES 2011-2014.Frontiers in aging neuroscience · 2024Article
- Risk Polymorphisms ofInternational journal of molecular sciences · 2023Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
introductionThere is limited and inconsistent reporting on the association between Life's Simple 7 (LS7) and dementia in the elderly population.
methodsBased on the Washington Heights-Inwood Columbia Aging Project (WHICAP), LS7 scores were estimated to assess cardiovascular health status. Associations between LS7 scores and incident dementia were investigated by Cox proportional hazards models.
resultsAmong 1987 subjects, 291 incident cases of dementia were identified over a median follow-up of 5.84 years. Compared with subjects in the poor cardiovascular health group (scores 0 to 5), those in intermediate (6 to 9) and optimal (10 to 14) groups had lower dementia risk, with the hazard ratio (HR; 95% confidence interval) being 0.74 (0.54 to 1.00) and 0.59 (0.38 to 0.91), respectively. These results were significant in apolipoprotein E genotype ε4 (APOE ε4) allele non-carriers but not in carriers. DISCUSSION: Higher LS7 scores are protective for dementia, especially among the APOE ε4 noncarriers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.