Evidence map›Paper›PMID 33938323›Full record

ArticleToxicologic pathology2021

Role for Mucin-5AC in Upper and Lower Airway Pathogenesis in Mice.

Hye-Youn Cho, Soojung Park, Laura Miller, Huei-Chen Lee, Robert Langenbach, Steven R Kleeberger

Open access · greenAbstract read
In one paragraph

Article in Toxicologic pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Mucins and Respiratory Virus Infection.Annual review of virology · 2026
    Review
  3. Article
  4. Molecular Hydrogen in the Treatment of Respiratory Diseases.International journal of molecular sciences · 2025
    Review
  5. Review
  6. Review
  7. Article
  8. [The role of ozone in the pathogenesis of allergic rhinitis].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2024
    Review
  9. Review
  10. Article
  11. Article
  12. Role of mucociliary clearance system in respiratory diseases.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023
    Article
  13. Article
  14. Article
  15. Mucus and Mucins: The Underappreciated Host Defence System.Frontiers in cellular and infection microbiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Hye-Youn ChoImmunity, Inflammation and Disease Laboratory, 6857National Institute of Environmental Health Sciences, National Institutes of Health, NC, USA.ORCID 0000-0002-8671-8544
Soojung ParkSignal Transduction Laboratory, 6857National Institute of Environmental Health Sciences, National Institutes of Health, NC, USA.
Laura MillerImmunity, Inflammation and Disease Laboratory, 6857National Institute of Environmental Health Sciences, National Institutes of Health, NC, USA.
Huei-Chen LeeSignal Transduction Laboratory, 6857National Institute of Environmental Health Sciences, National Institutes of Health, NC, USA.
Robert LangenbachSignal Transduction Laboratory, 6857National Institute of Environmental Health Sciences, National Institutes of Health, NC, USA.
Steven R KleebergerImmunity, Inflammation and Disease Laboratory, 6857National Institute of Environmental Health Sciences, National Institutes of Health, NC, USA.
National Institutes of Health · US

Funding

Molecular Genetics Support to Identify Gene/Environment Interactions in DiseaseZICES102546 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI GERRISH, KEVIN · 2009 to 2025
$30.5M
The Role Of Nrf2 In Susceptibility To Hyperoxic Lung InjuryZIAES100513 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI KLEEBERGER, STEVEN R · 2009 to 2021
$11.5M
Intramural NIH HHS Z99 ES999999
6 · The paper itself

Abstract

Mucin-5AC (MUC5AC) is a major secreted mucin in pathogenic airways. To determine its role in mucus-related airway disorders,

Indexed as

Mucin 5ACMucin-5BAnimalsLungMiceMucin 5ACMucin-5BfibrosislungmouseMUC5ACnasal airwayozonerespiratory syncytial virus

Identifiers

PMID33938323
PMCPMC8195843
OpenAlexW3157356805

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.