Evidence map›Paper›PMID 33940234›Full record

ArticleJournal of neuroimmunology2021

The μ-opioid receptor induces miR-21 expression and is ERK/PKCμ-dependent.

Jen-Kuan Chang, William D Cornwell, Thomas J Rogers

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroimmunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jen-Kuan ChangCenter for Inflammation, Translational and Clinical Lung Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
William D CornwellCenter for Inflammation, Translational and Clinical Lung Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
Thomas J RogersCenter for Inflammation, Translational and Clinical Lung Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA. Electronic address: rogerst@temple.edu.
Temple University · US

Funding

Pilot Projects Core (PPC)P30DA013429 · NIDA · TEMPLE UNIV OF THE COMMONWEALTH · PI SCOTT M. RAWLS · 2000 to 2026
$34.6M
Opioid &Chemokine Receptor Interactions Relative to HIVR01DA014230 · NIDA · TEMPLE UNIV OF THE COMMONWEALTH · PI ROGERS, THOMAS J · 2001 to 2016
$5.0M
Inflammation associated with HIV infection: role of receptor cross-talkR01DA049745 · NIDA · TEMPLE UNIV OF THE COMMONWEALTH · PI PERSIDSKY, YURI, ROGERS, THOMAS J · 2019 to 2023
$3.3M
HIV-induced neuroinflammation associated with opioid abuse and tobacco smokeR01DA040619 · NIDA · TEMPLE UNIV OF THE COMMONWEALTH · PI PERSIDSKY, YURI, ROGERS, THOMAS J · 2016 to 2020
$3.2M
NIDA NIH HHS P30 DA013429NIDA NIH HHS R01 DA014230NIDA NIH HHS R01 DA040619NIDA NIH HHS R01 DA049745
6 · The paper itself

Abstract

Micro RNA-21 (miR-21) is believed to perform an important role in the transition from inflammation to resolution in the innate immune response. The biochemical basis for the induction of miR-21 remains uncertain. However, the activation of the μ-opioid receptor (MOR) induces the expression of miR-21. Our results show that human monocytes treated with μ-opioid agonists exhibit a significant increase in miR-21 expression. We found that MOR-induction of miR-21 requires the activation of the Ras-Raf-MEK-ERK signaling cascade, and to our surprise, the activation of PKCμ (PKD1). These results are significant given the role of miR-21 in the sensitivity to pain.

Indexed as

Analgesics, OpioidCells, CulturedDose-Response Relationship, DrugEnkephalin, Ala(2)-MePhe(4)-Gly(5)-Gene ExpressionHEK293 CellsHumansLeukocytes, MononuclearMAP Kinase Signaling SystemMicroRNAsProtein Kinase CReceptors, Opioid, muAnalgesics, OpioidEnkephalin, Ala(2)-MePhe(4)-Gly(5)-MicroRNAsMIRN21 microRNA, humanProtein Kinase Cprotein kinase DReceptors, Opioid, mumicroRNAMiR-21MonocytePKCμPKD

Identifiers

PMID33940234
PMCPMC8169580
OpenAlexW3158815823

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.