Evidence map›Paper›PMID 33945405›Full record

ArticleRNA biology2021

The translation initiation factor EIF4E5 from Leishmania: crystal structure and interacting partners.

Gustavo Barbosa de Lima, Thaíse Yasmine Vasconcelos de Lima Cavalcanti, Adriana Neuman Albuquerque Lins Moura de Brito, Ludmilla Arruda de Assis, Rafaela Paiva Andrade-Vieira, Eden Ribeiro Freire, Tatiana Reichert da Silva Assunção, Christian Robson de Souza Reis, Nilson Ivo Tonin Zanchin, Beatriz Gomes Guimarães and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RNA biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Gustavo Barbosa de LimaDepartamento de Microbiologia, Instituto Aggeu Magalhães, FIOCRUZ-PE, Av. Moraes Rego s/n, Recife-PE, Brazil.
Thaíse Yasmine Vasconcelos de Lima CavalcantiDepartamento de Microbiologia, Instituto Aggeu Magalhães, FIOCRUZ-PE, Av. Moraes Rego s/n, Recife-PE, Brazil.
Adriana Neuman Albuquerque Lins Moura de BritoDepartamento de Microbiologia, Instituto Aggeu Magalhães, FIOCRUZ-PE, Av. Moraes Rego s/n, Recife-PE, Brazil.
Ludmilla Arruda de AssisDepartamento de Microbiologia, Instituto Aggeu Magalhães, FIOCRUZ-PE, Av. Moraes Rego s/n, Recife-PE, Brazil.
Rafaela Paiva Andrade-VieiraDepartamento de Microbiologia, Instituto Aggeu Magalhães, FIOCRUZ-PE, Av. Moraes Rego s/n, Recife-PE, Brazil.
Eden Ribeiro FreireDepartamento de Microbiologia, Instituto Aggeu Magalhães, FIOCRUZ-PE, Av. Moraes Rego s/n, Recife-PE, Brazil.
Tatiana Reichert da Silva AssunçãoLaboratório de Biologia Estrutural e Engenharia de Proteínas, Instituto Carlos Chagas, FIOCRUZ-PR, Curitiba-PR, Brazil.
Christian Robson de Souza ReisDepartamento de Microbiologia, Instituto Aggeu Magalhães, FIOCRUZ-PE, Av. Moraes Rego s/n, Recife-PE, Brazil.
Nilson Ivo Tonin ZanchinLaboratório de Biologia Estrutural e Engenharia de Proteínas, Instituto Carlos Chagas, FIOCRUZ-PR, Curitiba-PR, Brazil.ORCID 0000-0002-1153-0694
Beatriz Gomes GuimarãesLaboratório de Biologia Estrutural e Engenharia de Proteínas, Instituto Carlos Chagas, FIOCRUZ-PR, Curitiba-PR, Brazil.ORCID 0000-0002-8546-2460
Osvaldo Pompílio de-Melo-NetoDepartamento de Microbiologia, Instituto Aggeu Magalhães, FIOCRUZ-PE, Av. Moraes Rego s/n, Recife-PE, Brazil.ORCID 0000-0001-5402-7346
Fundação Oswaldo Cruz · BRFundação Carlos Chagas · BRUniversidade Federal de Pernambuco · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mRNA cap-binding protein, eIF4E, mediates the recognition of the mRNA 5' end and, as part of the heterotrimeric eIF4F complex, facilitates the recruitment of the ribosomal subunits to initiate eukaryotic translation. Various regulatory events involving eIF4E and a second eIF4F subunit, eIF4G, are required for proper control of translation initiation. In pathogenic trypanosomatids, six eIF4Es and five eIF4Gs have been described, several forming different eIF4F-like complexes with yet unresolved roles. EIF4E5 is one of the least known of the trypanosomatid eIF4Es and has not been characterized in

Indexed as

Protein Interaction MapsAmino Acid SequenceBinding SitesCrystallography, X-RayEukaryotic Initiation Factor-4EHumansLeishmaniaProtein BindingProtein ConformationProtozoan ProteinsSequence HomologyEukaryotic Initiation Factor-4EProtozoan Proteinscrystal structureEIF4E5Leishmaniaprotein interactionTranslation initiation

Identifiers

PMID33945405
PMCPMC8632131
OpenAlexW3158529073

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.