Evidence map›Paper›PMID 33947048›Full record

ArticleInternational journal of molecular sciences2021

Hemistepsin a Induces Apoptosis of Hepatocellular Carcinoma Cells by Downregulating STAT3.

Il Je Cho, Jae Kwang Kim, Eun Ok Kim, Sang Mi Park, Sang Chan Kim, Sung Hwan Ki, Sae Kwang Ku

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Hemistepsin A induces apoptosis by modulating the reactive oxygen species-dependent PI3K/Akt signaling pathway in human lung carcinoma A549 cells.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Il Je ChoCollege of Korean Medicine, Daegu Haany University, Gyeongsan 38610, Korea.ORCID 0000-0001-6295-0608
Jae Kwang KimCollege of Korean Medicine, Daegu Haany University, Gyeongsan 38610, Korea.ORCID 0000-0003-1410-7688
Eun Ok KimCollege of Korean Medicine, Daegu Haany University, Gyeongsan 38610, Korea.
Sang Mi ParkCollege of Korean Medicine, Daegu Haany University, Gyeongsan 38610, Korea.
Sang Chan KimCollege of Korean Medicine, Daegu Haany University, Gyeongsan 38610, Korea.
Sung Hwan KiCollege of Pharmacy, Chosun University, Gwangju 61452, Korea.ORCID 0000-0003-0761-3750
Sae Kwang KuCollege of Korean Medicine, Daegu Haany University, Gyeongsan 38610, Korea.ORCID 0000-0003-1269-3804
Daegu Haany University · KRChosun University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antineoplastic Agents, PhytogenicApoptosisCarcinoma, HepatocellularCell Line, TumorDown-RegulationDrug Screening Assays, AntitumorGene Expression Regulation, NeoplasticGenes, ReporterHumansLactonesLiver NeoplasmsNeoplasm ProteinsOxidative StressProtein Kinase InhibitorsRecombinant ProteinsSesquiterpenesAntineoplastic Agents, PhytogenichemistepsinLactonesNeoplasm ProteinsProtein Kinase InhibitorsRecombinant ProteinsSesquiterpenesSorafenibSTAT3 protein, humanSTAT3 Transcription Factorapoptosishemistepsin A (HsA)Hemistepta lyrata (Bunge) Bungehepatocellular carcinoma (HCC) cellsoxidative stresssignal transducer and activator of transcription 3 (STAT3)sorafenib

Identifiers

PMID33947048
PMCPMC8125382
OpenAlexW3158771744

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.