SynthesisBMC medicine2021
Functional connectivity changes in cerebral small vessel disease - a systematic review of the resting-state MRI literature.
Synthesis in BMC medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07372937 (Investigating Neural Correlates of Gait Abnormalities in Patients With Cerebral Small Vessel Disease), which is not on this map. Cited by 44 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigating Neural Correlates of Gait Abnormalities in Patients With Cerebral Small Vessel Disease
Who cites it
44 citing papers in PubMed, 3 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Mapping the multi-scale landscape of vascular cognitive impairment: from structural atrophy networks to cellular and neurochemical substrates.Journal of neurology · 2026Pooled it
- AES-SDM meta-analysis of spontaneous brain activity in cerebral small vessel disease.BMC medical imaging · 2026Pooled it
- Impact of hypertension on brain function assessed by resting state functional MRI (rs-fMRI): a systematic review and meta-analysis.Brain imaging and behavior · 2026Pooled it
- Posture-Related Regional Homogeneity Abnormalities in Cerebral Small Vessel Disease: A Multi-Position MRI Study.CNS neuroscience & therapeutics · 2026Article
- Bridging structure and function: triple network remodeling driven by white matter hyperintensities in vascular cognitive impairment.GeroScience · 2026Article
- Impaired white matter functional networks topology changed with white matter hyperintensities burden and relationship to cognition.Brain imaging and behavior · 2026Article
- Multimodal voxel-wise of structural and functional brain alterations across the cerebral small vessel disease spectrum.Neuroradiology · 2026Article
- Modeling Complex Effects and Individual Variability in Multi-Paradigm fMRI with Nonlinear Mixed Models.bioRxiv : the preprint server for biology · 2026Article
- Article
- Magnetic Resonance Imaging- Derived Cerebral Small Vessel Disease Burden and Association with Domain-Specific Cognition: A Cross-Sectional Study.Annals of Indian Academy of Neurology · 2026Article
- Vascular Cognitive Impairment and Dementia: Clinical Features, Neuropathology, and Biomarkers.Journal of the American College of Cardiology · 2026Review
- Advances in brain MRI for CAD-associated cognitive impairment with supplementary perspectives from traditional Chinese medicine.Frontiers in medicine · 2026Review
- Specific genetic and biological patterns underlying cortical morphological alterations in vascular cognitive impairment.Alzheimer's research & therapy · 2025Article
- Alterations of structural-functional connectivity coupling in older adults with depressive symptoms.Psychological medicine · 2025Article
- The hidden burden: cerebral small vessel disease and cognitive reappraisal failure in memory clinic older adults.Brain imaging and behavior · 2025Article
- Olfactory identification impairment in cerebral small-vessel disease indicates cognitive network disconnection and predicts accelerated cognitive decline.Journal of neurology · 2025Article
- The Impact of Cerebral Small Vessel Disease on Functional Recovery After Intracerebral Hemorrhage: Stratified Analysis by Age.Journal of clinical medicine · 2025Article
- Metabolic Remapping at "Point-Line-Plane" Levels With Central Dysfunction in Cerebral Small Vessel Disease.Brain and behavior · 2025Article
- Alterations in static and dynamic functional network connectivity in subcortical vascular cognitive impairment.Scientific reports · 2025Article
- The Relationship Between Brain Frailty and Physical Function in Patients With Stroke Undergoing Rehabilitation.Cureus · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCerebral small vessel disease (CSVD) is a common neurological disease present in the ageing population that is associated with an increased risk of dementia and stroke. Damage to white matter tracts compromises the substrate for interneuronal connectivity. Analysing resting-state functional magnetic resonance imaging (fMRI) can reveal dysfunctional patterns of brain connectivity and contribute to explaining the pathophysiology of clinical phenotypes in CSVD. MATERIALS AND
methodsThis systematic review provides an overview of methods and results of recent resting-state functional MRI studies in patients with CSVD. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) protocol, a systematic search of the literature was performed.
resultsOf 493 studies that were screened, 44 reports were identified that investigated resting-state fMRI connectivity in the context of cerebral small vessel disease. The risk of bias and heterogeneity of results were moderate to high. Patterns associated with CSVD included disturbed connectivity within and between intrinsic brain networks, in particular the default mode, dorsal attention, frontoparietal control, and salience networks; decoupling of neuronal activity along an anterior-posterior axis; and increases in functional connectivity in the early stage of the disease.
conclusionThe recent literature provides further evidence for a functional disconnection model of cognitive impairment in CSVD. We suggest that the salience network might play a hitherto underappreciated role in this model. Low quality of evidence and the lack of preregistered multi-centre studies remain challenges to be overcome in the future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.