ArticleThe British journal of general practice : the journal of the Royal College of General Practitioners2021
Potentially inappropriate primary care prescribing in people with chronic kidney disease: a cross-sectional analysis of a large population cohort.
Article in The British journal of general practice : the journal of the Royal College of General Practitioners, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Widespread inappropriate prescribing for older people with reduced kidney function: what are the harms and how do we tackle them? A scoping review for primary care.BMJ quality & safety · 2026Article
- Creatinine clearance, reduced kidney function, and optimizing prescribing safety through practice feedback: a mixed methods study.Family practice · 2025Article
- The relationship between physical inactivity and sexual dysfunction among patients receiving hemodialysis.International urology and nephrology · 2025Article
- Ten-Year Trend in the Potentially Inappropriate Prescribing of Renally-Dependent Medicines in Australian General Practice Patients with Dementia.Journal of clinical medicine · 2025Article
- The prevalence and contributing factors of NSAIDs prescription among chronic kidney disease patients in primary care: a mixed methods study from Kingdom of Bahrain.BMC primary care · 2025Article
- Article
- Medications for community pharmacists to dose adjust or avoid to enhance prescribing safety in individuals with advanced chronic kidney disease: a scoping review and modified Delphi.BMC nephrology · 2024Article
- Best-Practice Perspectives on Improving Early Detection and Management of Chronic Kidney Disease Associated With Type 2 Diabetes in Primary Care.Clinical diabetes : a publication of the American Diabetes Association · 2024Article
- Optimizing Collaborative Care of Patients with Chronic Kidney Disease Associated with Type 2 Diabetes: An Example Practice Model at a Health Care Practice in Kentucky, United States.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2024Article
- Commentary: Potentially inappropriate medication among older patients with diabetic kidney disease.Frontiers in pharmacology · 2023Article
- Impact of Potentially Inappropriate Medications on Kidney Function in Chronic Kidney Disease: Retrospective Cohort Study.Nephron · 2023Article
- Polypharmacy and medication use in patients with chronic kidney disease with and without kidney replacement therapy compared to matched controls.Clinical kidney journal · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMany drugs should be avoided or require dose-adjustment in chronic kidney disease (CKD). Previous estimates of potentially inappropriate prescribing rates have been based on data on a limited number of drugs, and mainly in secondary care settings.
aimTo determine the prevalence of contraindicated and potentially inappropriate primary care prescribing in a complete population of people with known CKD. DESIGN AND
settingCross-sectional study of prescribing patterns in a complete geographical population of people with CKD, defined using laboratory data.
methodDrugs were organised by British National Formulary advice - contraindicated drugs: 'avoid'; potentially high-risk (PHR) drugs: 'avoid if possible'; and dose-inappropriate (DI) drugs: 'dose exceeded recommended maximums'. CKD was defined as estimated glomerular filtration rate (eGFR)
resultsIn total, 28 489 people with CKD were included in the analysis, of whom 70.1% had CKD stage 3a, 22.4% CKD stage 3b, 5.9% CKD stage 4, and 1.5% CKD stage 5. A total of 3.9% (95% confidence interval [CI] = 3.7 to 4.1) of people with CKD stages 3a-5 were prescribed
conclusionPotentially inappropriate prescribing is common at all stages of CKD. Development and evaluation of interventions to improve prescribing safety in this high-risk population are needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.