Evidence map›Paper›PMID 33948980›Full record

ArticleHistopathology2022

Burkitt lymphoma with a granulomatous reaction: an M1/Th1-polarised microenvironment is associated with controlled growth and spontaneous regression.

Massimo Granai, Stefano Lazzi, Virginia Mancini, Ayse Akarca, Raffaella Santi, Federica Vergoni, Ester Sorrentino, Raffaella Guazzo, Lucia Mundo, Gabriele Cevenini and 15 more

Open access · hybridAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Histopathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Pediatric lymphomas: overview and diagnostic challenges.Virchows Archiv : an international journal of pathology · 2025
    Review
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  5. Review
  6. Aflatoxin B1 and Epstein-Barr virus-induced CCL22 expression stimulates B cell infection.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 12 institutions in 7 countries.

Massimo GranaiDepartment of Medical Biotechnologies, University of Siena, Siena, Italy.
Stefano LazziDepartment of Medical Biotechnologies, University of Siena, Siena, Italy.
Virginia ManciniDepartment of Medical Biotechnologies, University of Siena, Siena, Italy.
Ayse AkarcaDepartment of Cellular Pathology, University College London, London, UK.
Raffaella SantiDepartment of Pathology, University of Florence, Florence, Italy.
Federica VergoniDepartment of Pathology, University of Florence, Florence, Italy.
Ester SorrentinoDepartment of Medical Biotechnologies, University of Siena, Siena, Italy.
Raffaella GuazzoDepartment of Medical Biotechnologies, University of Siena, Siena, Italy.
Lucia MundoDepartment of Medical Biotechnologies, University of Siena, Siena, Italy.
Gabriele CeveniniDepartment of Medical Biotechnologies, University of Siena, Siena, Italy.
Claudio TripodoDepartment of Human Pathology, University of Palermo, Palermo, Italy.
Gioia Di StefanoDepartment of Pathology, University of Florence, Florence, Italy.
Benedetta PucciniDepartment of Haematology, University of Florence, Florence, Italy.
Maurilio PonzoniDepartment of Pathology, University Vita-Salute San Raffaele, Milano, Italy.
Elena SabattiniHaemolymphopathology Unit - IRCCS - Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.ORCID https://orcid.org/0000-0002-4136-3591
Claudio AgostinelliHaemolymphopathology Unit - IRCCS - Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.ORCID https://orcid.org/0000-0002-4945-1422
Nuray BassüllüDepartment of Pathology, Bilim University, İstanbul, Turkey.
Tülay TecimerDepartment of Pathology, Acibadem University, İstanbul, Turkey.
Ahu Senem DemirozDepartment of Pathology, İstanbul University Cerrahpaşa, İstanbul, Turkey.
Leah MnangoDepartment of Pathology, Muhimbili National Hospital and University for Healthcare and Allied Sciences, Dar-es-Salaam, Tanzania.
Stephan DirnhoferInstitute of Pathology, University Hospital Basel, Basel, Switzerland.
Leticia Quintanilla-MartinezInstitute of Pathology, University of Tübingen, Tübingen, Germany.ORCID https://orcid.org/0000-0001-7156-5365
Teresa MarafiotiDepartment of Cellular Pathology, University College London, London, UK.
Falko FendDepartment of Medical Biotechnologies, University of Siena, Siena, Italy.
Lorenzo LeonciniDepartment of Medical Biotechnologies, University of Siena, Siena, Italy.ORCID https://orcid.org/0000-0002-7457-300X
University of Siena · ITUniversity of Florence · ITAzienda USL di Bologna · ITUniversity College London · GBAcıbadem University · TRIstanbul Bilim University · TRIstanbul University-Cerrahpaşa · TRMuhimbili University of Health and Allied Sciences · TZUniversity Hospital of Basel · CHUniversity of Palermo · ITUniversity of Tübingen · DEVita-Salute San Raffaele University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsBurkitt lymphoma (BL) is an aggressive B-cell lymphoma that, in some instances, may show a granulomatous reaction associated with a favourable prognosis and occasional spontaneous regression. In the present study, we aimed to define the tumour microenvironment (TME) in four such cases, two of which regressed spontaneously. METHODS AND

resultsAll cases showed aggregates of tumour cells with the typical morphology, molecular cytogenetics and immunophenotype of BL surrounded by a florid epithelioid granulomatous reaction. All four cases were Epstein-Barr virus (EBV)-positive with type I latency. Investigation of the TME showed similar features in all four cases. The analysis revealed a proinflammatory response triggered by Th1 lymphocytes and M1 polarised macrophages encircling the neoplastic cells with a peculiar topographic distribution.

conclusionsOur data provide an in-vivo picture of the role that specific immune cell subsets might play during the early phase of BL, which may be capable of maintaining the tumour in a self-limited state or inducing its regression. These novel results may provide insights into new potential therapeutic avenues in EBV-positive BL patients in the era of cellular immunotherapy.

Indexed as

Tumor MicroenvironmentAdolescentAgedBurkitt LymphomaEpstein-Barr Virus InfectionsFemaleHerpesvirus 4, HumanHumansMacrophagesMaleMiddle AgedTh1 CellsBurkitt lymphomaEBVgranulomatous reactionin-situ lymphoid neoplasiaM1 polarised macrophagesmicroenvironmentTh1 T cells

Identifiers

PMID33948980
PMCPMC9291779
OpenAlexW3159112713

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.