Evidence map›Paper›PMID 33949206›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2021

Enhanced epithelial sodium channel activity in neonatal Scnn1b mouse lung attenuates high oxygen-induced lung injury.

Garett J Grant, Patrice N Mimche, Robert Paine, Theodore G Liou, Wei-Jun Qian, My N Helms

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Carbon dioxide and MAPK signalling: towards therapy for inflammation.Cell communication and signaling : CCS · 2023
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Garett J GrantDivision of Respiratory, Critical Care and Occupational Pulmonary Medicine, Department of Internal Medicine, University of Utah, Salt Lake City, Utah.
Patrice N MimcheDivision of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, Utah.
Robert PaineDivision of Respiratory, Critical Care and Occupational Pulmonary Medicine, Department of Internal Medicine, University of Utah, Salt Lake City, Utah.ORCID 0000-0002-4511-4437
Theodore G LiouDivision of Respiratory, Critical Care and Occupational Pulmonary Medicine, Department of Internal Medicine, University of Utah, Salt Lake City, Utah.ORCID 0000-0003-0121-4847
Wei-Jun QianBiological Science Division, Pacific Northwest National Laboratory, Richland, Washington.ORCID 0000-0002-5393-2827
My N HelmsDivision of Respiratory, Critical Care and Occupational Pulmonary Medicine, Department of Internal Medicine, University of Utah, Salt Lake City, Utah.
University of Utah · USPacific Northwest National Laboratory · US

Funding

ZINC GLUCONATE GLYCINE LOZENGES &VITAMIN C EFFECTS ON COMMON COLDM01RR000042 · NCRR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI YANIK, GREGORY A · 1985 to 2007
$40.8M
Utah Center for Clinical and Translational ScienceUL1TR002538 · NCATS · UNIVERSITY OF UTAH · PI HESS, RACHEL, MAJERSIK, JENNIFER JUHL · 2018 to 2022
$26.0M
EphB/EphrinB signaling in Systemic SclerosisR01AR076489 · NIAMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI MIMCHE, PATRICE · 2020 to 2025
$2.0M
Oxidized glutathione regulation of epithelial sodium channels in newborn lung injuryR01HL137033 · NHLBI · UNIVERSITY OF UTAH · PI HELMS, MY N. · 2018 to 2021
$1.5M
Explanatory models of CF Survival, Infection and Intermediate Clinical OutcomesR01HL125520 · NHLBI · UNIVERSITY OF UTAH · PI LIOU, THEODORE GEH-LU · 2015 to 2018
$1.4M
EphB2 receptor tyrosine kinase in liver fibrosisR21DK115991 · NIDDK · UNIVERSITY OF UTAH · PI MIMCHE, PATRICE · 2018 to 2020
$572k
Oxygen, Pulmonary Innate Immunity and Alveolar Epithelial Cell GM-CSFI01BX001777 · VA · VA SALT LAKE CITY HEALTHCARE SYSTEM · PI PAINE, ROBERT · 2013 to 2023
–
BLRD VA I01 BX001777NCATS NIH HHS UL1 TR002538NCRR NIH HHS M01 RR000042NHLBI NIH HHS R01 HL125520NHLBI NIH HHS R01 HL137033NIAMS NIH HHS R01 AR076489NIDDK NIH HHS R21 DK115991
6 · The paper itself

Abstract

Prolonged oxygen therapy leads to oxidative stress, epithelial dysfunction, and acute lung injury in preterm infants and adults. Heterozygous Scnn1b mice, which overexpress lung epithelial sodium channels (ENaC), and their wild-type (WT) C57Bl6 littermates were utilized to study the pathogenesis of high fraction inspired oxygen ([Formula: see text])-induced lung injury. Exposure to high [Formula: see text] from birth to

Indexed as

Acute Lung InjuryEpithelial Sodium ChannelsOxygenAmilorideAnimalsEpithelial Sodium Channel BlockersFemaleGlutathione DisulfideMaleMiceMice, Inbred C57BLAmilorideEpithelial Sodium Channel BlockersEpithelial Sodium ChannelsGlutathione DisulfideOxygenScnn1b protein, mousealveolar fluid clearanceepithelial sodium channelflavin adenine dinucleotide (FAD)oxidative stressS-glutathionylation

Identifiers

PMID33949206
PMCPMC8321857
OpenAlexW3159136825

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.