ArticleBrain and behavior2021
Depression and anxiety symptoms are related to pain and frailty but not cognition or delirium in older surgical patients.
Article in Brain and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07633483 (Assessment of the Relationship Between Preoperative Anxiety Level Measured by the Hamilton Anxiety Rating Scale and Frailty Score Assessed by the FRAIL Scale in Elderly Patients Aged 65 Years and Older Scheduled for Elective Hip Arthroplasty), which is not on this map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Assessment of the Relationship Between Preoperative Anxiety Level Measured by the Hamilton Anxiety Rating Scale and Frailty Score Assessed by the FRAIL Scale in Elderly Patients Aged 65 Years and Older Scheduled for Elective Hip Arthroplasty: A Prospective Observational Single-Center Study
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Efficacy and safety of perioperative application of ketamine on postoperative depression: A meta-analysis of randomized controlled studies.Molecular psychiatry · 2023Pooled it
- Perioperative Depression and Anxiety Care in Older Patients: A Randomized Clinical Trial.JAMA network open · 2026Trial
- Efficacy and Safety of Oliceridine for Patient-Controlled Intravenous Analgesia in Elderly Patients Undergoing Laparoscopic Radical Resection Surgery for Gastrointestinal Malignant Tumors: A Prospective Randomized Controlled Non-Inferiority Clinical Trial.Drug design, development and therapy · 2026Trial
- The investigation of effect on foot plantar massage on functional recovery in older adults with general surgery, randomized clinical trial.Aging clinical and experimental research · 2024Trial
- Trial
- Development and Validation of a Frailty Risk Prediction Model for Preoperative Non-Small-Cell Lung Cancer Patients: A Cross-Sectional Study.Annals of surgical oncology · 2026Article
- Relationship Between Postoperative Pain in Surgery and the Onset of Psychological Symptoms Such as Mental Anxiety and Depression.Actas espanolas de psiquiatria · 2026Article
- The association between anxiety levels and postoperative pain following endodontic treatment: a prospective observational study.BMC oral health · 2026Observational
- Depression in older surgical patients: a multicentre prospective longitudinal study.British journal of anaesthesia · 2026Article
- Article
- Causal relationship between branched-chain amino acids and their metabolites and frailty: A two-sample Mendelian randomization study.Medicine · 2025Article
- Analysis of frailty change trajectories and its risk factors in patients with gastrointestinal tumor surgery: a prospective observational longitudinal study.World journal of surgical oncology · 2025Observational
- Psychopathological Influences on Surgical and Clinical Outcomes in Lumbar Disk Herniation: Prediction Models and Literature Analysis.Journal of personalized medicine · 2025Article
- Isoflurane anesthesia decreases excitability of inhibitory neurons in the basolateral amygdala leading to anxiety‑like behavior in aged mice.Experimental and therapeutic medicine · 2024Article
- Preoperative frailty predicts postoperative pain after total knee arthroplasty in older patients: a prospective observational study.European geriatric medicine · 2024Observational
- History of Psychoactive Medication a Risk Factor for Neurocognitive Decline After Cardiac Surgery.The Journal of surgical research · 2024Article
- Preoperative Anxiety Impact on Anesthetic and Analgesic Use.Medicina (Kaunas, Lithuania) · 2023Review
- Patients' Perceptions and Experiences during the Pre-Admission Phase for Total Hip Replacement Surgery: A Qualitative Phenomenological Study.Journal of clinical medicine · 2023Article
- Correlation and influencing factors of preoperative anxiety, postoperative pain, and delirium in elderly patients undergoing gastrointestinal cancer surgery.BMC anesthesiology · 2023Article
- Study on anxiety and depression in elderly patients with malignant liver tumor undergoing hepatectomy.European journal of medical research · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 1 country.
Funding
Abstract
objectiveIn community dwelling older adults, depression and anxiety symptoms can be associated with early cognitive decline. Symptoms of depression and anxiety are common in older adults prior to surgery. However, their significance is unknown. Our objective was to determine whether preoperative depression and anxiety symptoms are associated with postoperative cognitive decline (POCD) and in-hospital delirium, in older surgical patients.
methodsWe conducted a secondary data analysis of postoperative cognitive dysfunction in a cohort study of patients 65 and older undergoing elective noncardiac surgery. We used the Hospital Anxiety and Depression Scale (HADS) to screen for depression and anxiety symptoms at a home visit prior to surgery and 3 months after surgery. Patients with a history of psychiatric (major depressive disorder, bipolar disorder, and schizophrenia) or neurologic disorder (Parkinson's disease and stroke) were excluded from the parent study.
resultsOut of the 167 patients, 9.6% (n = 16) reported significant depressive symptoms and 21.6% (n = 36) reported significant anxiety symptoms on preoperative screening. There was no association between preoperative or new-onset postoperative depression and anxiety symptoms and the incidence of delirium or POCD three months after surgery. Patients with preoperative depressive symptoms had higher preoperative pain (scores 69 vs. 35.7, p = .002) and frailty (56 vs. 14.6, p <.001).
conclusionIn our cohort, we did not detect an association between preoperative depression and anxiety symptoms and neurocognitive disorders. Preoperative depression and anxiety symptoms were related to physical pain and frailty. Taken together, these suggest that in patients without a formal psychiatric diagnosis, preoperative depression and anxiety symptoms are related to physical state rather than a harbinger of early cognitive decline. Future studies are needed to understand the nature of the relationship between depression and anxiety symptoms and physical state in surgical patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.