Evidence map›Paper›PMID 33949892›Full record

ArticleJournal of neurophysiology2021

Acute intrathecal BDNF enhances functional recovery after cervical spinal cord injury in rats.

Gary C Sieck, Heather M Gransee, Wen-Zhi Zhan, Carlos B Mantilla

Open access · greenAbstract read
In one paragraph

Article in Journal of neurophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
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  5. An update on spinal cord injury and diaphragm neuromotor control.Expert review of respiratory medicine · 2025
    Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
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  16. Article
  17. Spinal cord injury: molecular mechanisms and therapeutic interventions.Signal transduction and targeted therapy · 2023
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Gary C SieckDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota.
Heather M GranseeDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota.
Wen-Zhi ZhanDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota.
Carlos B MantillaDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota.
Mayo Clinic · US

Funding

Respiratory Control in Old AgeR01AG044615 · NIA · MAYO CLINIC ROCHESTER · PI MANTILLA, CARLOS B, SIECK, GARY C. · 2013 to 2025
$6.9M
Enhancing Respiratory Motor Function after Spinal Cord InjuryR01HL146114 · NHLBI · MAYO CLINIC ROCHESTER · PI Carlos B Mantilla, Gary C. Sieck · 2019 to 2026
$5.4M
Recovery of Respiratory Function After Spinal Cord InjuryR01HL096750 · NHLBI · MAYO CLINIC ROCHESTER · PI MANTILLA, CARLOS B, SIECK, GARY C. · 2010 to 2017
$4.9M
NHLBI NIH HHS R01 HL096750NHLBI NIH HHS R01 HL146114NIA NIH HHS R01 AG044615
6 · The paper itself

Abstract

Unilateral C

Indexed as

AnimalsBrain-Derived Neurotrophic FactorCervical CordDiaphragmDisease Models, AnimalElectromyographyInjections, SpinalMaleRatsRats, Sprague-DawleyRecovery of FunctionSpinal Cord InjuriesBrain-Derived Neurotrophic Factordiaphragm muscleneurotrophinsphrenic motor neuronsrespiratory neural control

Identifiers

PMID33949892
PMCPMC8285661
OpenAlexW3157152684

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.