Evidence map›Paper›PMID 33950474›Full record

ArticleNeurochemical research2021

Ilex kudingcha C.J. Tseng Mitigates Phenotypic Characteristics of Human Autism Spectrum Disorders in a Drosophila Melanogaster Rugose Mutant.

Hang Thi Nguyet Pham, Hong Nguyen Tran, Xoan Thi Le, Ha Thi Do, Tue Trong Nguyen, Chien Le Nguyen, Hideki Yoshida, Masamistu Yamaguchi, Folk R William, Kinzo Matsumoto

Abstract read
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In one paragraph

Article in Neurochemical research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Hang Thi Nguyet PhamNational Institute of Medicinal Materials, Hoan Kiem District, Hanoi, 110100, Vietnam. nguyethangpt@nimm.org.vn.ORCID http://orcid.org/0000-0002-6490-1508
Hong Nguyen TranNational Institute of Medicinal Materials, Hoan Kiem District, Hanoi, 110100, Vietnam.
Xoan Thi LeNational Institute of Medicinal Materials, Hoan Kiem District, Hanoi, 110100, Vietnam.
Ha Thi DoNational Institute of Medicinal Materials, Hoan Kiem District, Hanoi, 110100, Vietnam.
Tue Trong NguyenHanoi Medical University, Dong Da District, Hanoi, 116001, Vietnam.
Chien Le NguyenMilitary Medical Academy, Ha Dong District, Hanoi, 100000, Vietnam.
Hideki YoshidaKyoto Institute of Technology, Matsugasaki, Kyoto, Sakyo-ku, 606-8585, Japan.
Masamistu YamaguchiKyoto Institute of Technology, Matsugasaki, Kyoto, Sakyo-ku, 606-8585, Japan.
Folk R WilliamDepartment of Biochemistry, University of Missouri, Columbia, MO, 65211, USA.
Kinzo MatsumotoCenter for Supporting Pharmaceutical Education, Daiichi University of Phamacy, Fukuoka, 815-8511, Japan.
National Library of Vietnam · VNKyoto Institute of Technology · JPDaiichi University of Pharmacy · JPHanoi Medical University · VNUniversity of Missouri · USVietnam Military Medical University · VN

Funding

National Foundation for Science and Technology Development 108.05-2018.319
6 · The paper itself

Abstract

Autism spectrum disorders (ASD) have heterogeneous etiologies involving dysfunction of central nervous systems, for which no effective pan-specific treatments are available. Ilex kudingcha (IK) C.J. Tseng is a nootropic botanical used in Asia for neuroprotection and improvement of cognition. This study establishes that a chemically characterized extract from IK (IKE) mitigates behavioral traits in the Drosophila melanogaster rugose mutant, whose traits resemble human ASD, and examines possible mechanisms. IKE treatment significantly ameliorated deficits in social interaction, short-term memory, and locomotor activity in Drosophila rugose, and significantly increased synaptic bouton number of size more than 2 μm

Indexed as

AnimalsAutism Spectrum DisorderCircadian RhythmDrosophila melanogasterGene ExpressionHippocampusHumansIlexLocomotionMemory, Short-TermMethylphenidateNootropic AgentsPhenotypePlant ExtractsPlant LeavesPresynaptic TerminalsMethylphenidateNootropic AgentsPlant ExtractsAutism spectrum disorderDopaminergic synapsesaDrosophila melanogaster rugoseIlex kudingcha

Identifiers

PMID33950474
OpenAlexW3158444592

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.