Evidence map›Paper›PMID 33952255›Full record

ArticleLipids in health and disease2021

Screening for the presence of scleroedema adultorum of Buschke in patients with diabetes mellitus: newly diagnosed patients had a high prevalence of dyslipidaemia.

Viktória Csonka, Beáta Bódis, Dániel Kovács, Nelli Farkas, Endre Kálmán, László Czirják, Cecília Varjú

Registry-linked trialOpen access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lipids in health and disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04335396 (Screening Patients With Diabetes Mellitus for the Presence of Scleredema Adultorum of Buschke and Characterize Clinical-laboratory Findings of the Newly Identified Cases), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04335396 unknown statusnot on this map

Screening Patients With Diabetes Mellitus for the Presence of Scleredema Adultorum of Buschke and Characterize Clinical-laboratory Findings of the Newly Identified Cases: a Single-center, Prospective, Obsevational Study

TypeobservationalSponsorUniversity of PecsRan2018 to 2023Enrolled150ConditionsDiabetes Mellitus, Diabetes Complications, Scleroderma-Like Changes, Scleredema Adultorum
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Viktória CsonkaDepartment of Rheumatology and Immunology, Medical School, University of Pécs, Akác u. 1, Pécs, H-7632, Hungary.ORCID http://orcid.org/0000-0001-9288-5755
Beáta Bódis1st Department of Internal Medicine, Medical School, University of Pécs, Pécs, Hungary.
Dániel KovácsDepartment of Vascular Surgery, Medical School, University of Pécs, Pécs, Hungary.
Nelli FarkasInstitute of Bioanalysis, Medical School, University of Pécs, Pécs, Hungary.
Endre KálmánDepartment of Pathology, Medical School, University of Pécs, Pécs, Hungary.
László CzirjákDepartment of Rheumatology and Immunology, Medical School, University of Pécs, Akác u. 1, Pécs, H-7632, Hungary.
Cecília VarjúDepartment of Rheumatology and Immunology, Medical School, University of Pécs, Akác u. 1, Pécs, H-7632, Hungary. varju.cecilia@pte.hu.
University of Pecs · HUSomogy Megyei Kaposi Mór Oktató Kórház · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundScleroedema adultorum of Buschke is a rare disorder characterized by fibromucinous thickening of the dermis that manifests mainly at the nape of the neck and on the upper back and shoulders. This study screened patients with diabetes mellitus for skin hardening caused by scleroedema adultorum of Buschke and characterized the clinical and laboratory findings in patients with newly identified cases, with a focus on lipid metabolism abnormalities and vascular complications.

methodsOut of 113 consecutive patients with diabetes, 11 (9.7%) new scleroedema patients, all with type 2 diabetes, were found. Their clinical and laboratory data were compared to those of the rest of the screened patients and to those of a cohort of 15 patients with scleroedema and diabetes who were already being treated in a tertiary clinical centre at the University of Pécs.

resultsHigher proportions of patients with dyslipidaemia, hypertriglyceridemia (P < 0.05) and increased mean levels of non-high-density lipoprotein cholesterol (non-HDL-C) were found (P < 0.01) in both scleroedema groups than in the group without scleroedema. Stroke and venous thromboembolism (VTE) were more frequently found in the histories of both the newly identified scleroedema group (each 3/11; 27.3%) and the treated cohort (each 6/15; 40.0%) than in the group without scleroedema (6/102; 5.9% in cases of stroke P = 0.021, P < 0.001; and 14/102; 13.7%; P < 0.05 in cases of VTE, respectively). Based on binary logistic regression, a high non-HDL-C level (odds ratio (OD): 3.338, confidence interval (CI): 1.77-6.28; P < 0.001) and insulin treatment (OR 7.64, CI 1.9-29.3; P = 0.003) were independent predictors of scleroedema in patients with diabetes mellitus.

conclusionsDiabetes patients with scleroedema had more severe dyslipidaemia and higher occurrence of vascular complications compared to those without scleroedema. In addition to poorly controlled type 2 diabetes mellitus requiring insulin treatment, high non-HDL-C levels may be another contributing factor to the development of scleroedema.

trial registrationNCT04335396 .

Indexed as

Diabetes Mellitus, Type 2DyslipidemiasFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsLipidsLogistic ModelsMaleMass ScreeningMiddle AgedPrevalenceRisk FactorsScleredema AdultorumSkinHydroxymethylglutaryl-CoA Reductase InhibitorsLipidsDiabetes mellitusDyslipidaemiaFibromucinous thickeningNon-alcoholic fatty liver disease (NAFLD)Scleroderma-likeScleroedema

Identifiers

PMID33952255
PMCPMC8101242
OpenAlexW3158875500

What Socratic holds

Textfull text, public
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.