SynthesisCardiovascular revascularization medicine : including molecular interventions2022
Systemic Inflammation May Induce Cardiac Injury in COVID-19 Patients Including Children and Adolescents Without Underlying Cardiovascular Diseases: A Systematic Review.
Synthesis in Cardiovascular revascularization medicine : including molecular interventions, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Severity of the Omicron SARS-CoV-2 variant compared with the previous lineages: A systematic review.Journal of cellular and molecular medicine · 2023Pooled it
- Cardiovascular and haematological events post COVID-19 vaccination: A systematic review.Journal of cellular and molecular medicine · 2022Pooled it
- Trend in Hospital Admissions for Cardiovascular Diseases (CVDs) Before and During the Coronavirus Disease 2019 (COVID-19) Pandemic: A Retrospective Analysis From a Sub-Urban Area in Sub-Saharan Africa.Health science reports · 2026Article
- Assessing ECG Findings in Pediatric COVID-19 Patients: A Comprehensive Analysis.Current cardiology reviews · 2026Article
- The Epidemiological and Clinical Profiling of Heart Failure-A Retrospective and Comparative Analysis of Cases Before, During, and After the COVID-19 Pandemic in a Romanian Emergency County Clinical Hospital.Medicina (Kaunas, Lithuania) · 2025Observational
- Weathering the Storm: How Age and Biologics Influence the COVID-19 Cytokine Surge.Pathogens (Basel, Switzerland) · 2025Review
- Observational
- Impact of underlying diseases and complications on COVID-19 mortality in South Korea: analysis of national health insurance service data.Archives of public health = Archives belges de sante publique · 2025Article
- Prognostic Value of Caspase-3 and Cardiac Troponin I in Assessing Cardiovascular Risk in Pediatric COVID-19 and Multisystem Inflammatory Syndrome.Journal of multidisciplinary healthcare · 2025Article
- Co-infections exacerbate inflammatory responses in COVID-19 patients, promoting coagulopathy and myocardial injury, leading to increased disease severity.Frontiers in immunology · 2025Article
- COVID-19: a multi-organ perspective.Frontiers in cellular and infection microbiology · 2024Review
- Association of New-Onset Atrial Fibrillation With All-Cause Mortality in COVID-19 Patients.Cureus · 2023Article
- Risk of arrhythmias following COVID-19: nationwide self-controlled case series and matched cohort study.European heart journal open · 2023Article
- Post -acute sequalae of COVID-19 and cardiac outcomes in U. S. military members.International journal of cardiology. Cardiovascular risk and prevention · 2023Article
- COVID-19's immuno-pathology and cardiovascular diseases.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2023Review
- Progranulin (PGRN) as a regulator of inflammation and a critical factor in the immunopathogenesis of cardiovascular diseases.Journal of inflammation (London, England) · 2023Review
- Cardiac Involvement in Children Affected by COVID-19: Clinical Features and Diagnosis.Diagnostics (Basel, Switzerland) · 2022Review
- Effect of the COVID-19 outbreak on emergency transport of children by an emergency medical service system: a population-based, ORION registry study.BMC emergency medicine · 2022Article
- Electrocardiographic Abnormalities in Hospitalized Patients with COVID-19 and the Associations with Clinical Outcome.Journal of clinical medicine · 2022Article
- Role of Endomyocardial Biopsy in Diagnostics of Myocarditis.Diagnostics (Basel, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coronavirus disease 2019(COVID-19) is an ongoing global pandemic with a daily increasing number of affected individuals and a relatively high mortality rate. COVID-19 patients that develop cardiac injury are at increased risk of a worse clinical course with higher rates of mortality. Increasing amounts of evidence suggest that a system-wide inflammatory response and a cytokine storm mediated type syndrome plays a crucial role in disease progression. This systematic review investigates the possible role of hyperinflammation in inducing cardiac injury as one of the severe complications of COVID-19. A systematic literature search was performed using PubMed, Embase and Scopus databases to identify relevant clinical studies that investigated cardiovascular injury manifestations and reported inflammatory and cardiac biomarkers in COVID-19 patients. Only 29 studies met our inclusion criteria and the majority of these studies demonstrated significantly elevated inflammatory and cardiac blood markers. It was evident that underlying cardiovascular diseases may increase the risk of developing cardiac injury. However, many COVID-19 patients included in this review, developed different types of cardiac injury without having any underlying cardiovascular diseases. Furthermore, many of these patients were either children or adolescents. Therefore, age and comorbidities may not always be the two main risk factors that dictate the severity and outcome of COVID-19. Further investigations are required to understand the underlying mechanisms of pathogenicity as an urgent requirement to develop the appropriate treatment and prevention strategies. These strategies may specifically target hyperinflammation as a suspected driving factor for some of the severe complications of COVID-19.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.