Evidence map›Paper›PMID 33953602›Full record

ArticlePharmacogenomics and personalized medicine2021

Evaluation of

Lorena Díaz-Ordóñez, Diana Ramírez-Montaño, Estephania Candelo, Carolina González-Restrepo, Sebastián Silva-Peña, Carlos Arturo Rojas, Mario Sepulveda Copete, Hector Raul Echavarria, Harry Pachajoa

Open access · goldAbstract read
In one paragraph

Article in Pharmacogenomics and personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Genetic variants ofJournal of Taibah University Medical Sciences · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. [First-Line Eradication ofActa gastroenterologica Latinoamericana
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Lorena Díaz-OrdóñezBasic Medical Science Department, Faculty of Health Sciences, Universidad Icesi, Cali, Colombia.ORCID 0000-0002-3140-6332
Diana Ramírez-MontañoBasic Medical Science Department, Faculty of Health Sciences, Universidad Icesi, Cali, Colombia.ORCID 0000-0001-9424-7554
Estephania CandeloClinical Genetic Department, Fundación Valle del Lili, Cali, Colombia.ORCID 0000-0003-3002-7071
Carolina González-RestrepoBasic Medical Science Department, Faculty of Health Sciences, Universidad Icesi, Cali, Colombia.
Sebastián Silva-PeñaBasic Medical Science Department, Faculty of Health Sciences, Universidad Icesi, Cali, Colombia.ORCID 0000-0002-1637-7510
Carlos Arturo RojasGastroenterology Department, Fundacion Valle del Lili, Cali, Colombia.
Mario Sepulveda CopeteGastroenterology Department, Fundacion Valle del Lili, Cali, Colombia.
Hector Raul EchavarriaCentro Medico Imbanaco, Cali, Colombia.
Harry PachajoaBasic Medical Science Department, Faculty of Health Sciences, Universidad Icesi, Cali, Colombia.ORCID 0000-0003-2672-0439
Fundación Valle del Lili · COIcesi University · COCaucaseco Scientific Research Center · CO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background

resultsWe identified nine polymorphisms, six of which had no reported functions. One of these genetic variants, with a functional impact, not yet reported (p.Arg132Trp) was predicted by bioinformatic tools as potentially pathogenic. This finding suggests that p.Arg132Trp could be related to poor metabolizers of drugs metabolized by CYP2C19.

conclusionWe identified the genotype spectrum of variants in

Indexed as

computational biologycytochrome P450 CYP2C19pharmacogeneticsproton pump inhibitorssingle nucleotide polymorphismtreatment failure

Identifiers

PMID33953602
PMCPMC8092628
OpenAlexW3157892813

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.