Evidence map›Paper›PMID 33958235›Full record

ArticlePlacenta2021

Placental structural abnormalities in gestational diabetes and when they develop: A scoping review.

Erin Ehlers, Omonseigho O Talton, Danny J Schust, Laura C Schulz

Open access · greenAbstract readScoping Review
PubMed Full text at PMC Publisher
In one paragraph

Article in Placenta, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 3 pooled it
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 84 citations in OpenAlex.

  1. Gestational diabetes mellitus and vascular malperfusion lesions in the placenta: A systematic review and meta-analysis.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Erin EhlersDepartment of Obstetrics, Gynecology and Women's Health, University of Missouri, Columbia, MO, USA.
Omonseigho O TaltonDepartment of Biology, Avila University, USA.
Danny J SchustDepartment of Obstetrics, Gynecology and Women's Health, University of Missouri, Columbia, MO, USA.
Laura C SchulzDepartment of Obstetrics, Gynecology and Women's Health, University of Missouri, Columbia, MO, USA. Electronic address: schulzL@missouri.edu.
University of Missouri · USAvila University · USUniversity of Missouri Health System · US

Funding

Modeling Normal and Abnormal TrophoblastsR01HD094937 · UNIVERSITY OF MISSOURI-COLUMBIA · 2025 to 2025
$607k
NICHD NIH HHS R01 HD094937NICHD NIH HHS R03 HD105831
6 · The paper itself

Abstract

Gestational diabetes mellitus (GDM) is defined as diabetes with onset or first recognition during gestation. It is a common complication of pregnancy that has become more prevalent over the past few decades. Abnormalities in fetal growth, including increased incidence of both large and small for gestational age babies, suggest placental dysfunction. The major goal of this scoping review is to determine what is known about abnormalities in placentas delivered from GDM pregnancies, and how early in gestation these abnormalities arise. A secondary goal is to review to what extent other selected factors, in particular obesity, have been found to influence or modify the reported effects of GDM on placental development, and whether these are considered in the study of GDM placentas. PubMed and Scopus databases were searched using the key terms: "gestational diabetes AND (woman OR human) AND placenta AND (ultrasound OR ultrastructure OR imaging OR histology OR pathology). Studies of gross morphology and histoarchitecture in placentas delivered from GDM pregnancies consistently report increased placental size, villous immaturity and a range of vascular lesions when compared to uncomplicated pregnancies. In contrast, a small number of ultrasound studies have examined placental development in GDM pregnancies in the second, and especially, the first trimester. Relatively few studies have analyzed interactions with maternal BMI, but these do suggest that it may play a role in placental abnormalities. Further examination of placental development early in pregnancy is needed to understand when it becomes disrupted in GDM, as a first step to identifying the underlying causes.

Indexed as

Diabetes, GestationalFemaleHumansPlacentaPregnancyUltrasonography, PrenatalGestational diabetesPlacental pathologyPlacental ultrasound

Identifiers

PMID33958235
PMCPMC9295324
OpenAlexW3159631768

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.