ArticleNeuropsychiatric disease and treatment2021
Handgrip Strength and Depression Among Older Chinese Inpatients: A Cross-Sectional Study.
Article in Neuropsychiatric disease and treatment, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 21 citations in OpenAlex.
- Relationship between triglyceride-glucose index and muscle strength in middle-aged and older Chinese adults without chronic diseases: a nationwide longitudinal cohort study.Scientific reports · 2026Article
- Associations between muscle strength and mental health in older adults.Revista da Associacao Medica Brasileira (1992) · 2026Article
- Emotional state in patients after COVID-19 in relation to comprehensive rehabilitation, Brain-Derived neurotrophic factor, Irisin levels, and selected clinical factors.Scientific reports · 2025Article
- From Breath to Strength: Does Mindfulness Improve Handgrip Strength Among Older Adults in India? A Propensity Score Matching Analysis.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2025Article
- Association of GLIM-defined malnutrition with depressive mood in older adults undergoing rehabilitation.European journal of clinical nutrition · 2025Article
- Possible sarcopenia and depression among middle-aged and older adults in China: A 9-year longitudinal survey.PloS one · 2025Article
- The association of depressive symptoms with handgrip strength and gait speed in community-dwelling older adults: data from the baseline phase of Birjand Longitudinal Aging Study.BMC geriatrics · 2024Article
- Grip strength and depressive symptoms in Chinese middle-aged and older adults: the mediating effects of cognitive function.Frontiers in aging neuroscience · 2024Article
- Effects of early mental state changes on physical functions in elderly patients with a history of falls.BMC geriatrics · 2023Article
- Analysis of the association between osteoporosis and muscle strength in Korean adults: a national cross-sectional study.Journal of health, population, and nutrition · 2023Article
- Possible-sarcopenic screening with disturbed plasma amino acid profile in the elderly.BMC geriatrics · 2023Article
- Association between handgrip strength and depression among Chinese older adults: a cross-sectional study from the China Health and Retirement Longitudinal Study.BMC geriatrics · 2023Article
- Dose-response association of handgrip strength and risk of depression: a longitudinal study of 115 601 older adults from 24 countries.The British journal of psychiatry : the journal of mental science · 2023Article
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8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThere have been studies exploring the association between handgrip and depression among community-dwelling adults; however, evidence for this association among hospitalized older adults is scarce. We aimed to use a larger-scale population from multiple centers to explore the association between low handgrip strength and depression.
methodsThis was a cross-sectional study that included hospitalized patients aged 65 years or older from different hospitals in China. Depression was assessed by a short-form Chinese Geriatric Depression Scale (GDS-15) with a cutoff value of 5 points or more. Dominant hand handgrip strength was assessed by a dynamometer. A generalized additive model and multivariable regression analysis were conducted.
resultsThere were 9,368 participants, with an average age of 72.4 (SD=5.7) in the final analysis. The prevalence of low handgrip strength and depressive symptoms among older Chinese hospitalized patients was 50.3% and 16.3%, respectively. There seemed to be a nonlinear relationship between handgrip strength and depression, and curve fitting and threshold analyses indicated that when handgrip strength was less than 35.6 kg, the depression risk decreased significantly with increasing handgrip strength. However, this association between handgrip strength and depression was not significant when the handgrip strength was greater than 35.6 kg. In addition, after adjusting for potential confounders, older patients with low handgrip strength had an increased risk of depression compared to those with normal handgrip strength (OR=1.46; 95% CI=1.27-1.68). The subgroup analysis found the results were unchanged.
conclusionOur study indicates that low handgrip strength was associated with a higher risk of depression among older Chinese hospitalized patients, implying that early patient screening for handgrip strength and initiating effective intervention programs, such as resistance training and nutritional supplements, could be helpful for older patients.
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