Evidence map›Paper›PMID 33959494›Full record

ArticleFrontiers in oncology2021

The Human Cytomegalovirus US31 Gene Predicts Favorable Survival and Regulates the Tumor Microenvironment in Gastric Cancer.

Sisi Ye, Yuanbo Hu, Chenbin Chen, Sian Chen, Xinya Tong, Huanbo Zhu, Bo Deng, Xianjing Hu, Xiangwei Sun, Xiadong Chen and 8 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 1 country.

Sisi YeDepartment of Medical Microbiology and Immunology, Wenzhou Medical University, Wenzhou, China.
Yuanbo HuDepartment of Medical Microbiology and Immunology, Wenzhou Medical University, Wenzhou, China.
Chenbin ChenDepartment of Medical Microbiology and Immunology, Wenzhou Medical University, Wenzhou, China.
Sian ChenDepartment of Medical Microbiology and Immunology, Wenzhou Medical University, Wenzhou, China.
Xinya TongDepartment of Medical Microbiology and Immunology, Wenzhou Medical University, Wenzhou, China.
Huanbo ZhuDepartment of Medical Microbiology and Immunology, Wenzhou Medical University, Wenzhou, China.
Bo DengDepartment of Medical Microbiology and Immunology, Wenzhou Medical University, Wenzhou, China.
Xianjing HuDepartment of Medical Microbiology and Immunology, Wenzhou Medical University, Wenzhou, China.
Xiangwei SunDepartment of Medical Microbiology and Immunology, Wenzhou Medical University, Wenzhou, China.
Xiadong ChenDepartment of Medical Microbiology and Immunology, Wenzhou Medical University, Wenzhou, China.
Xinyu ShiDepartment of Medical Microbiology and Immunology, Wenzhou Medical University, Wenzhou, China.
Ruihong GuDepartment of Medical Microbiology and Immunology, Wenzhou Medical University, Wenzhou, China.
Wangkai XieDepartment of Medical Microbiology and Immunology, Wenzhou Medical University, Wenzhou, China.
Gangqiang GuoDepartment of Medical Microbiology and Immunology, Wenzhou Medical University, Wenzhou, China.
Dong XingDepartment of Medical Microbiology and Immunology, Wenzhou Medical University, Wenzhou, China.
Xian ShenDepartment of Gastrointestinal Surgery, Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Xiangyang XueDepartment of Medical Microbiology and Immunology, Wenzhou Medical University, Wenzhou, China.
Shurong ShenWenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Zhejiang Chinese Medical University, Wenzhou, China.
Wenzhou Medical University · CNSecond Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University · CNFirst Affiliated Hospital of Wenzhou Medical University · CNZhejiang Chinese Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human cytomegalovirus (HCMV) is an oncogenic virus associated with tumorigenesis. Our previous study revealed that the HCMV US31 gene interacted with NF-κB2 and mediated inflammation through macrophages. However, there are few reports on the role of US31 in gastric cancer (GC). The aim of this study was to investigate the expression of the US31 gene in GC tissue and assess its role in the occurrence and development of GC. US31 expression in 573 cancer tissues was analyzed using immunohistochemistry. Results showed that US31 was significantly associated with tumor size (

Indexed as

gastric cancerhuman cytomegalovirusprognostic factortumor immune microenvironmentUS31

Identifiers

PMID33959494
PMCPMC8093799
OpenAlexW3154342623

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.