Evidence map›Paper›PMID 33959878›Full record

ArticleDermatology and therapy2021

Burden of Herpes Zoster in Adult Patients with Underlying Conditions: Analysis of German Claims Data, 2007-2018.

Manuel Batram, Julian Witte, Magdalena Schwarz, Johannes Hain, Bernhard Ultsch, Maren Steinmann, Amit Bhavsar, Peter Wutzler, Carl-Peter Criée, Christiane Hermann and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Dermatology and therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 6 pooled it
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 6 syntheses or guidelines pooled it, 52 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Global herpes zoster burden in adults with COPD: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2026
    Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Observational
  8. Article
  9. Age-Specific Risk of Herpes Zoster in Adults Aged ≥18 Years With Comorbid Conditions-A Retrospective Cohort Study in the United States.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Observational
  15. Article
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  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 2 countries.

Manuel BatramDepartment for Economics, Bielefeld University, P.O. Box 100131, 33501, Bielefeld, Germany. mbatram@uni-bielefeld.de.ORCID http://orcid.org/0000-0003-4445-965X
Julian WitteDepartment for Health Economics and Health Care Management, Bielefeld University, Universitätsstrasse 25, 33615, Bielefeld, Germany.ORCID http://orcid.org/0000-0003-2075-323X
Magdalena SchwarzGSK, Prinzregentenplatz 9, 81675, Munich, Germany.ORCID http://orcid.org/0000-0002-4850-8597
Johannes HainGSK, Prinzregentenplatz 9, 81675, Munich, Germany.ORCID http://orcid.org/0000-0002-2956-418X
Bernhard UltschGSK, Prinzregentenplatz 9, 81675, Munich, Germany.ORCID http://orcid.org/0000-0001-6685-2992
Maren SteinmannDepartment for Health Economics and Health Care Management, Bielefeld University, Universitätsstrasse 25, 33615, Bielefeld, Germany.ORCID http://orcid.org/0000-0003-0350-360X
Amit Bhavsar, GSK, Avenue Fleming 20, 1300, Wavre, Belgium.ORCID http://orcid.org/0000-0002-5956-2003
Peter WutzlerSection of Experimental Virology, Institute of Medical Microbiology, University-Hospital Jena, 07740, Jena, Germany.ORCID http://orcid.org/0000-0003-1063-1757
Carl-Peter CriéeDepartment of Sleep and Respiratory Medicine, Evangelical Hospital Goettingen-Weende, 37120, Bovenden, Germany.
Christiane HermannDepartment of Clinical Psychology, Justus-Liebig University Giessen, Otto-Behaghel-Strasse 10F, 35394, Giessen, Germany.ORCID http://orcid.org/0000-0001-5969-2898
Klaus WahleDepartment of General Medicine, University of Muenster, Domagkstr. 3, 48129, Muenster, Germany.ORCID http://orcid.org/0000-0002-2811-7150
Martin FüchtenbuschDiabeteszentrum am Marienplatz, Rindermarkt 3, 80331, Munich, Germany.
Wolfgang GreinerDepartment for Health Economics and Health Care Management, Bielefeld University, Universitätsstrasse 25, 33615, Bielefeld, Germany.ORCID http://orcid.org/0000-0001-9552-6969
Bielefeld University · DEMorphoSys (Germany) · DEEvangelisches Krankenhaus Göttingen-Weende · DEGlaxoSmithKline (Belgium) · BEHelmholtz Zentrum München · DEJena University Hospital · DEJustus-Liebig-Universität Gießen · DEUniversity of Münster · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSeveral chronic underlying conditions (UCs) are known to be risk factors for developing herpes zoster (HZ) and to increase the severity of HZ and its risk of recurrence. The aim of this study was to investigate the incidence and recurrence of HZ in adult patients with one or multiple UCs.

methodsA retrospective cohort study based on claims data representing 13% of the statutory health insurance population from 2007 to 2018 in Germany was performed. Patients aged ≥ 18 years were included when at least one of the following UCs was diagnosed: asthma, chronic heart failure, chronic obstructive pulmonary disease (COPD), coronary heart disease (CHD), depression, diabetes mellitus type 1 or 2, and rheumatoid arthritis (RA). Exact matching was used to account for differences in the distribution of age and sex between the case and matched control cohorts. Multi-morbidity was considered in sensitivity analyses by analyzing patients with only one UC.

resultsPatients with asthma, CHD, COPD, depression, and RA had, on average, a 30% increased risk of developing acute HZ compared to patients without any UC. RA was found to have the highest odds ratio among these conditions, varying from 1.37 to 1.57 for all age groups. Patients with depression also showed a high risk of developing HZ. Analysis of recurrence indicated that patients with at least one UC in the age groups 18-49 years and 50-59 years had the highest risk for a recurrent HZ. After experiencing a first recurrence, patients, regardless of age group, had a two- to threefold higher risk for a second recurrence.

conclusionThis study of representative claims data shows a higher HZ incidence and recurrence frequency in patients with UCs. These results provide relevant information for national health care guidelines and disease management programs.

Indexed as

Claims dataHerpes zosterIncidenceRecurrenceUnderlying conditions

Identifiers

PMID33959878
PMCPMC8163947
OpenAlexW3159413942

What Socratic holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.