Evidence map›Paper›PMID 33960401›Full record

ArticleFEBS letters2021

The SLIM1 transcription factor is required for arsenic resistance in Arabidopsis thaliana.

Timothy O Jobe, Qi Yu, Felix Hauser, Qingqing Xie, Yuan Meng, Tim Maassen, Stanislav Kopriva, Julian I Schroeder

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 19 citations in OpenAlex.

  1. An atlas of plant selenium metabolism.The New phytologist · 2026
    Review
  2. Review
  3. Overexpression ofFrontiers in plant science · 2024
    Article
  4. Review
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Timothy O JobeBiocenter, Botanical Institute, University of Cologne, Germany.ORCID 0000-0002-5729-4981
Qi YuDivision of Biological Sciences, Cell and Developmental Biology Section, University of California, La Jolla, CA, USA.
Felix HauserDivision of Biological Sciences, Cell and Developmental Biology Section, University of California, La Jolla, CA, USA.
Qingqing XieDivision of Biological Sciences, Cell and Developmental Biology Section, University of California, La Jolla, CA, USA.
Yuan MengDivision of Biological Sciences, Cell and Developmental Biology Section, University of California, La Jolla, CA, USA.
Tim MaassenBiocenter, Botanical Institute, University of Cologne, Germany.
Stanislav KoprivaBiocenter, Botanical Institute, University of Cologne, Germany.ORCID 0000-0002-7416-6551
Julian I SchroederDivision of Biological Sciences, Cell and Developmental Biology Section, University of California, La Jolla, CA, USA.ORCID 0000-0002-3283-5972
University of California San Diego · USUniversity of Cologne · DESalk Institute for Biological Studies · US

Funding

Yeast Genetics and Stress Response Genes-BiomedicalP42ES010337 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TUKEY, ROBERT H · 2000 to 2022
$69.8M
NIEHS NIH HHS P42 ES010337
6 · The paper itself

Abstract

The transcriptional regulators of arsenic-induced gene expression remain largely unknown. Sulfur assimilation is tightly linked with arsenic detoxification. Here, we report that mutant alleles in the SLIM1 transcription factor are substantially more sensitive to arsenic than cadmium. Arsenic treatment caused high levels of oxidative stress in the slim1 mutants, and slim1 alleles were impaired in both thiol accumulation and sulfate accumulation. We further found enhanced arsenic accumulation in roots of slim1 mutants. Transcriptome analyses indicate an important role for SLIM1 in arsenic-induced tolerance mechanisms. The present study identifies the SLIM1 transcription factor as an essential component in arsenic tolerance and arsenic-induced gene expression. Our results suggest that the severe arsenic sensitivity of the slim1 mutants is caused by altered redox status.

Indexed as

ArabidopsisArabidopsis ProteinsArsenicDNA-Binding ProteinsDrug ResistancePlant RootsTranscription FactorsOxidative StressArabidopsis ProteinsArsenicDNA-Binding ProteinsEIL3 protein, ArabidopsisTranscription FactorsArabidopsis thalianaarsenicsulfur limitationtranscription factor

Identifiers

PMID33960401
PMCPMC8238853
OpenAlexW3159509622

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.