Evidence map›Paper›PMID 33967622›Full record

ReviewInternational journal of medical sciences2021

Circular RNAs in stem cell differentiation: a sponge-like role for miRNAs.

Jian Zhou, Cheng Qiu, Zhihua Fan, Tianyi Liu, Tang Liu

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jian ZhouDepartment of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, P. R. China.
Cheng QiuDepartment of Orthopaedic Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, P. R. China.
Zhihua FanXiangya School of Medicine, Central South University, Changsha, Hunan, 410013, P. R. China.
Tianyi LiuCheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, P. R. China.
Tang LiuDepartment of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, P. R. China.
Central South University · CNSecond Xiangya Hospital of Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circular RNAs (circRNAs) are novel endogenous non-coding RNAs that play a critical role during cellular signal transduction, gene transcription and translation. With the rapid advancement of bioinformatics analysis tools and high-throughput RNA sequencing, numerous circRNAs with important biological features have been identified. They function as competing endogenous RNAs (ceRNAs) of microRNAs and as such exhibit the potential to act as biomarkers for stem cell differentiation. In the recent past, several studies have shown the involvement of circRNAs in stem cells differentiation. The present review summarizes the molecular characteristics, biogenesis and mechanisms of newly identified circRNAs in the differentiation of stem cells. In conclusion, circRNAs regulate the stem cells differentiation

Indexed as

AnimalsCell DifferentiationComputational BiologyHumansMicroRNAsModels, AnimalProtein BiosynthesisRNA, CircularRNA, MessengerRNA-SeqStem CellsMicroRNAsRNA, CircularRNA, MessengerceRNACircRNAmiRNAspongesstem cell differentiation

Identifiers

PMID33967622
PMCPMC8100645
OpenAlexW3159004416

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.