Evidence map›Paper›PMID 33968932›Full record

ReviewFrontiers in cell and developmental biology2021

The Role of Notch, Hedgehog, and Wnt Signaling Pathways in the Resistance of Tumors to Anticancer Therapies.

Vivek Kumar, Mohit Vashishta, Lin Kong, Xiaodong Wu, Jiade J Lu, Chandan Guha, B S Dwarakanath

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
124citing papers in PubMed, 1 pooled it
14.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

124 citing papers in PubMed, 1 synthesis or guideline pooled it, 241 citations in OpenAlex.

  1. Bridging Radiotherapy to Immunotherapy: The IFN-JAK-STAT Axis.International journal of molecular sciences · 2021
    Pooled it
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64 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Vivek KumarR&D Dept, Shanghai Proton and Heavy Ion Center (SPHIC), Shanghai, China.
Mohit VashishtaR&D Dept, Shanghai Proton and Heavy Ion Center (SPHIC), Shanghai, China.
Lin KongShanghai Key Laboratory of Radiation Oncology (20dz2261000), Shanghai, China.
Xiaodong WuR&D Dept, Shanghai Proton and Heavy Ion Center (SPHIC), Shanghai, China.
Jiade J LuShanghai Key Laboratory of Radiation Oncology (20dz2261000), Shanghai, China.
Chandan GuhaAlbert Einstein College of Medicine, The Bronx, NY, United States.
B S DwarakanathR&D Dept, Shanghai Proton and Heavy Ion Center (SPHIC), Shanghai, China.
Center for High Pressure Science & Technology Advanced Research · CNFudan University Shanghai Cancer Center · CNThe Bronx Defenders · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Resistance to therapy is the major hurdle in the current cancer management. Cancer cells often rewire their cellular process to alternate mechanisms to resist the deleterious effect mounted by different therapeutic approaches. The major signaling pathways involved in the developmental process, such as Notch, Hedgehog, and Wnt, play a vital role in development, tumorigenesis, and also in the resistance to the various anticancer therapies. Understanding how cancer utilizes these developmental pathways in acquiring the resistance to the multi-therapeutic approach cancer can give rise to a new insight of the anti-therapy resistance mechanisms, which can be explored for the development of a novel therapeutic approach. We present a brief overview of Notch, Hedgehog, and Wnt signaling pathways in cancer and its role in providing resistance to various cancer treatment modalities such as chemotherapy, radiotherapy, molecular targeted therapy, and immunotherapy. Understanding the importance of these molecular networks will provide a rational basis for novel and safer combined anticancer therapeutic approaches for the improvement of cancer treatment by overcoming drug resistance.

Indexed as

anticancerHedgehog signalingNotch signalingresistancetherapytumorsWnt signaling

Identifiers

PMID33968932
PMCPMC8100510
OpenAlexW3156935377

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.