Evidence map›Paper›PMID 33969789›Full record

ArticleNanotoxicology2021

Enhanced antioxidant capacity prevents epitranscriptomic and cardiac alterations in adult offspring gestationally-exposed to ENM.

Amina Kunovac, Quincy A Hathaway, Mark V Pinti, Andrya J Durr, Andrew D Taylor, William T Goldsmith, Krista L Garner, Timothy R Nurkiewicz, John M Hollander

Open access · greenAbstract read
In one paragraph

Article in Nanotoxicology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Bridging maternal effects and epitranscriptomics: A novel perspective in developmental biology.Developmental dynamics : an official publication of the American Association of Anatomists · 2026
    Review
  2. SystemicBiomolecules · 2025
    Article
  3. Article
  4. Article
  5. A pilot study of mitochondrial response to an in vivo prosthetic joint Staphylococcus aureus infection model.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2024
    Article
  6. NNanotoxicology · 2023
    Article
  7. Article
  8. Review
  9. Article
  10. Nanoparticle-Induced mNanomaterials (Basel, Switzerland) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Amina KunovacDivision of Exercise Physiology, West Virginia University School of Medicine, Morgantown, WV, USA.
Quincy A HathawayDivision of Exercise Physiology, West Virginia University School of Medicine, Morgantown, WV, USA.
Mark V PintiMitochondria, Metabolism & Bioenergetics Working Group, West Virginia University School of Medicine, Morgantown, WV, USA.
Andrya J DurrDivision of Exercise Physiology, West Virginia University School of Medicine, Morgantown, WV, USA.
Andrew D TaylorDivision of Exercise Physiology, West Virginia University School of Medicine, Morgantown, WV, USA.
William T GoldsmithCenter for Inhalation Toxicology (iTOX), West Virginia University School of Medicine, Morgantown, WV, USA.
Krista L GarnerCenter for Inhalation Toxicology (iTOX), West Virginia University School of Medicine, Morgantown, WV, USA.
Timothy R NurkiewiczCenter for Inhalation Toxicology (iTOX), West Virginia University School of Medicine, Morgantown, WV, USA.
John M HollanderDivision of Exercise Physiology, West Virginia University School of Medicine, Morgantown, WV, USA.
West Virginia University · USBioEnergetics (United States) · US

Funding

West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI JUDITH FEINBERG · 2012 to 2026
$81.0M
THE ROLE OF HEF1 PROTEIN IN INVASION OF METASTATIC BREAST CANCERP20RR016440 · NCRR · WEST VIRGINIA UNIVERSITY · PI HARNER, JAMES · 2001 to 2010
$22.8M
WVU Flow Cytometry and Single Cell Core Facility (FCSCCF)P20GM121322 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Karen H Martin · 2018 to 2026
$22.4M
Remote Microvascular Dysfunction After Particulate Matter ExposureR01ES015022 · NIEHS · WEST VIRGINIA UNIVERSITY · PI NURKIEWICZ, TIMOTHY R · 2007 to 2021
$4.9M
West Virginia Flow Cytometry Core FacilityP30GM103488 · NIGMS · WEST VIRGINIA UNIVERSITY · PI CUFF, CHRISTOPHER F · 2012 to 2016
$4.8M
Stroke and Alzheimers Disease Related DementiasT32AG052375 · NIA · WEST VIRGINIA UNIVERSITY · PI Paul D Chantler, BERNARD G. SCHREURS · 2017 to 2026
$3.5M
miRNA Regulation of the Mitochondrial GenomeR01HL128485 · NHLBI · WEST VIRGINIA UNIVERSITY · PI HOLLANDER, JOHN M · 2017 to 2019
$1.3M
COBRE FOR SIGNAL TRANSDUCTION AND CANCER PHASE IIIP30RR032138 · NCRR · WEST VIRGINIA UNIVERSITY · PI GIBSON, LAURA F. · 2011 to 2011
$1.1M
miRNA Regulation of the Mitochondrial GenomeR56HL128485 · NHLBI · WEST VIRGINIA UNIVERSITY · PI HOLLANDER, JOHN M · 2015 to 2015
$410k
American Heart Association-American Stroke Association 17PRE33660333NCRR NIH HHS P20 RR016440NCRR NIH HHS P30 RR032138NHLBI NIH HHS R01 HL128485NHLBI NIH HHS R56 HL128485NIA NIH HHS T32 AG052375NIEHS NIH HHS R01 ES015022NIGMS NIH HHS P20 GM121322NIGMS NIH HHS P30 GM103488NIGMS NIH HHS U54 GM104942
6 · The paper itself

Abstract

Maternal engineered nanomaterial (ENM) exposure during gestation has been associated with negative long-term effects on cardiovascular health in progeny. Here, we evaluate an epitranscriptomic mechanism that contributes to these chronic ramifications and whether overexpression of mitochondrial phospholipid hydroperoxide glutathione peroxidase (mPHGPx) can preserve cardiovascular function and bioenergetics in offspring following gestational nano-titanium dioxide (TiO

Indexed as

NanostructuresPrenatal Exposure Delayed EffectsAdultAntioxidantsFemaleFetusHeartHumansMaternal ExposurePregnancyAntioxidantsEnvironmental exposureGPx4M6AmitochondriaN6-methyladenosine

Identifiers

PMID33969789
PMCPMC8363568
OpenAlexW3162972498

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.