Evidence map›Paper›PMID 33970327›Full record

Trial reportEuropean journal of applied physiology2021

Cocoa-flavanols enhance moderate-intensity pulmonary

Daniel G Sadler, Richard Draijer, Claire E Stewart, Helen Jones, Simon Marwood, Dick H J Thijssen

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of applied physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04370353 (Investigating the Impact of Cocoa Flavanol Supplementation on Pulmonary Oxygen Uptake Kinetics and Exercise Tolerance in Sedentary Middle-aged Adults), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04370353 nacompletednot on this map

Investigating the Impact of Cocoa Flavanol Supplementation on Pulmonary Oxygen Uptake Kinetics and Exercise Tolerance in Sedentary Middle-aged Adults

TypeinterventionalSponsorLiverpool John Moores UniversityRan2018 to 2019Enrolled18ConditionsAging, Sedentary BehaviorArmsCocoa flavanols, Placebo supplement
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Daniel G SadlerSchool of Sport and Exercise Science, Liverpool John Moores University, Byrom Street, Liverpool, L3 3AF, UK.
Richard DraijerUnilever Research & Development, Olivier van Noortlaan 120, 3133 AT, Vlaardingen, The Netherlands.
Claire E StewartSchool of Sport and Exercise Science, Liverpool John Moores University, Byrom Street, Liverpool, L3 3AF, UK.
Helen JonesSchool of Sport and Exercise Science, Liverpool John Moores University, Byrom Street, Liverpool, L3 3AF, UK.
Simon MarwoodSchool of Health Sciences, Liverpool Hope University, Liverpool, UK.
Dick H J ThijssenSchool of Sport and Exercise Science, Liverpool John Moores University, Byrom Street, Liverpool, L3 3AF, UK. D.Thijssen@ljmu.ac.uk.ORCID 0000-0002-7707-5567
Liverpool John Moores University · GBLiverpool Hope University · GBUnilever (Netherlands) · NL

Funding

Biotechnology and Biological Sciences Research Council BB/P504385/1
6 · The paper itself

Abstract

introductionCocoa flavanols (CF) may exert health benefits through their potent vasodilatory effects, which are perpetuated by elevations in nitric oxide (NO) bioavailability. These vasodilatory effects may contribute to improved delivery of blood and oxygen (O PURPOSE: Therefore, the objective of this study was to examine how CF supplementation impacts pulmonary O

methodsWe employed a double-blind cross-over, placebo-controlled design whereby 17 participants (11 male, 6 female; mean ± SD, 45 ± 6 years) randomly received either 7 days of daily CF (400 mg) or placebo (PL) supplementation. On day 7, participants completed a series of 'step' moderate- and severe-intensity exercise tests for the determination of

resultsDuring moderate-intensity exercise, the time constant of the phase II

conclusionOur data show that acute CF supplementation enhanced

trial registrationRegistered under ClinicalTrials.gov Identifier no. NCT04370353, 30/04/20 retrospectively registered.

Indexed as

Sedentary BehaviorCacaoCross-Over StudiesDouble-Blind MethodExercise TestExercise ToleranceFemaleFlavanonesHumansMaleMiddle AgedOxygen ConsumptionPulmonary CirculationVasodilationFlavanonesExercise toleranceFlavanolsHeart rateMiddle-ageOxygen uptake kinetics

Identifiers

PMID33970327
PMCPMC8260510
OpenAlexW3161302692

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.