Evidence map›Paper›PMID 33974405›Full record

ArticleACS infectious diseases2021

Deazapurine Nucleoside Analogues for the Treatment of

Manal J Natto, Fabian Hulpia, Eric R Kalkman, Susan Baillie, Amani Alhejeli, Yukiko Miyamoto, Lars Eckmann, Serge Van Calenbergh, Harry P de Koning

Open access · greenAbstract read
In one paragraph

Article in ACS infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Discovery of thienopyrimidine analog G-18 as a novel anti-trichomonal agent.International journal for parasitology. Drugs and drug resistance · 2026
    Article
  3. Review
  4. TargetingFrontiers in microbiology · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Cloning and Characterization ofInternational journal of molecular sciences · 2023
    Article
  9. Pyrimidine salvage inFrontiers in cellular and infection microbiology · 2023
    Article
  10. Phenotypic Evaluation of Nucleoside Analogues againstMolecules (Basel, Switzerland) · 2022
    Article
  11. TheMolecules (Basel, Switzerland) · 2022
    Article
  12. Nucleoside Transport and Nucleobase Uptake Null Mutants inInternational journal of molecular sciences · 2022
    Article
  13. AInternational journal of molecular sciences · 2022
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 4 countries.

Manal J NattoInstitute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, U.K.
Fabian HulpiaLaboratory for Medicinal Chemistry, Campus Heymans (FFW), Ghent University, Ottergemsesteenweg 460, B-9000 Gent, Belgium.
Eric R KalkmanInstitute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, U.K.
Susan BaillieInstitute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, U.K.
Amani AlhejeliInstitute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, U.K.
Yukiko Miyamoto
Serge Van CalenberghLaboratory for Medicinal Chemistry, Campus Heymans (FFW), Ghent University, Ottergemsesteenweg 460, B-9000 Gent, Belgium.ORCID 0000-0002-4201-1264
Harry P de KoningInstitute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, U.K.ORCID 0000-0002-9963-1827
Institute of Infection and Immunity · CAGhent University · BEUniversity of California San Diego · US

Funding

San Diego Digestive Diseases Research CenterP30DK120515 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Bernd G. Schnabl · 2019 to 2026
$10.8M
NIDDK NIH HHS P30 DK120515
6 · The paper itself

Abstract

Trichomoniasis is the most common nonviral sexually transmitted disease in humans, but treatment options are limited. Here, we report a resorufin-based drug sensitivity assay for high-throughput microplate-based screening under hypoxic conditions. A 5203-compound enamine kinase library and several specialized compound series were tested for the inhibition of

Indexed as

Sexually Transmitted DiseasesTrichomonas vaginalisAnimalsDrug ResistanceHigh-Throughput Screening AssaysHumansMiceNucleosidesNucleosideshigh-throughput screeningmouse modelnucleoside analogTrichomonas vaginalistubercidin

Identifiers

PMID33974405
PMCPMC9586919
OpenAlexW3162367538

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.