Evidence map›Paper›PMID 33975151›Full record

ArticlePsychoneuroendocrinology2021

Kisspeptin modulates gamma-aminobutyric acid levels in the human brain.

Alexander N Comninos, Lisa Yang, James O'Callaghan, Edouard G Mills, Matthew B Wall, Lysia Demetriou, Victoria C Wing, Layla Thurston, Bryn M Owen, Ali Abbara and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychoneuroendocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

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  5. Acute Effects of Kisspeptin Administration on Bone Metabolism in Healthy Men.The Journal of clinical endocrinology and metabolism · 2022
    Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Alexander N ComninosDivision of Diabetes, Endocrinology & Metabolism, Imperial College London, UK; Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK.
Lisa YangDivision of Diabetes, Endocrinology & Metabolism, Imperial College London, UK.
James O'CallaghanInvicro, London, UK.
Edouard G MillsDivision of Diabetes, Endocrinology & Metabolism, Imperial College London, UK.
Matthew B WallInvicro, London, UK.
Lysia DemetriouInvicro, London, UK; Nuffield Department of Women's and Reproductive Health, University of Oxford, UK.
Victoria C WingDivision of Diabetes, Endocrinology & Metabolism, Imperial College London, UK.
Layla ThurstonDivision of Diabetes, Endocrinology & Metabolism, Imperial College London, UK.
Bryn M OwenDivision of Diabetes, Endocrinology & Metabolism, Imperial College London, UK.
Ali AbbaraDivision of Diabetes, Endocrinology & Metabolism, Imperial College London, UK.
Eugenii A RabinerInvicro, London, UK.
Waljit S DhilloDivision of Diabetes, Endocrinology & Metabolism, Imperial College London, UK; Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK. Electronic address: w.dhillo@imperial.ac.uk.
Imperial College London · GBInvicro (United Kingdom) · GBUniversity of Oxford · GB

Funding

Department of Health NIHR RP-2014-05-001Medical Research Council MR/R000484/1Medical Research Council MR/T006242/1Wellcome TrustWellcome Trust 105545/Z/14/Z
6 · The paper itself

Abstract

Gamma-aminobutyric acid (GABA) is a key inhibitory neurotransmitter that has been implicated in the aetiology of common mood and behavioural disorders. By employing proton magnetic resonance spectroscopy in man, we demonstrate that administration of the reproductive neuropeptide, kisspeptin, robustly decreases GABA levels in the limbic system of the human brain; specifically the anterior cingulate cortex (ACC). This finding defines a novel kisspeptin-activated GABA pathway in man, and provides important mechanistic insights into the mood and behaviour-altering effects of kisspeptin seen in rodents and humans. In addition, this work has therapeutic implications as it identifies GABA-signalling as a potential target for the escalating development of kisspeptin-based therapies for common reproductive disorders of body and mind.

Indexed as

Braingamma-Aminobutyric AcidKisspeptinsHumansgamma-Aminobutyric AcidKisspeptinsAnterior cingulate cortexGamma-aminobutyric acid (GABA)KisspeptinLimbic systemReproductive behaviourSexual behaviour

Identifiers

PMID33975151
PMCPMC8243259
OpenAlexW3157597965

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.