Evidence map›Paper›PMID 33977597›Full record

ReviewGenes to cells : devoted to molecular & cellular mechanisms2021

Extension of chronological lifespan in Schizosaccharomyces pombe.

Hokuto Ohtsuka, Takafumi Shimasaki, Hirofumi Aiba

Abstract readReview
In one paragraph

Review in Genes to cells : devoted to molecular & cellular mechanisms, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Characterization of P-type HMolecular genetics and genomics : MGG · 2025
    Article
  4. Article
  5. Loss ofmicroPublication biology · 2025
    Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Extension of chronological lifespan in Schizosaccharomyces pombe.Genes to cells : devoted to molecular & cellular mechanisms · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hokuto OhtsukaLaboratory of Molecular Microbiology, Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Nagoya, Japan.ORCID https://orcid.org/0000-0001-7843-2602
Takafumi ShimasakiLaboratory of Molecular Microbiology, Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Nagoya, Japan.
Hirofumi AibaLaboratory of Molecular Microbiology, Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Nagoya, Japan.ORCID https://orcid.org/0000-0002-7775-0446

Funding

Ministry of Education, Culture, Sports, Science, and Technology of Japan JP17H03792Ministry of Education, Culture, Sports, Science, and Technology of Japan JP19K15730Ministry of Education, Culture, Sports, Science, and Technology of Japan JP20H02898
6 · The paper itself

Abstract

There are several examples in the nature wherein the mechanism of longevity control of unicellular organisms is evolutionarily conserved with that of higher multicellular organisms. The present microreview focuses on aging and longevity studies, particularly on chronological lifespan (CLS) concerning the unicellular eukaryotic fission yeast Schizosaccharomyces pombe. In S. pombe, >30 compounds, 8 types of nutrient restriction, and >80 genes that extend CLS have been reported. Several CLS control mechanisms are known to be involved in nutritional response, energy utilization, stress responses, translation, autophagy, and sexual differentiation. In unicellular organisms, the control of CLS is directly linked to the mechanism by which cells are maintained in limited-resource environments, and their genetic information is left to posterity. We believe that this important mechanism may have been preserved as a lifespan control mechanism for higher organisms.

Indexed as

Cell ProliferationGene Expression Regulation, FungalEnergy MetabolismSchizosaccharomycesagingchronological lifespanfission yeastlongevitySchizosaccharomyces pombestationary phase

Identifiers

PMID33977597
PMCPMC9290682

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.