Evidence map›Paper›PMID 33979838›Full record

Trial reportThe Journal of nutrition2021

Maternal Overweight and Obesity during Pregnancy Are Associated with Neonatal, but Not Maternal, Hepcidin Concentrations.

Andrew D Jones, Zhen Shi, Nathalie J Lambrecht, Yaping Jiang, Jingmin Wang, Margit Burmeister, Ming Li, Betsy Lozoff

Open access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Daily oral iron supplementation during pregnancy.The Cochrane database of systematic reviews · 2024
    Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Review
  7. Observational
  8. Fetal iron uptake from recent maternal diet and the maternal RBC iron pool.The American journal of clinical nutrition · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Andrew D JonesDepartment of Nutritional Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-9265-3935
Zhen ShiPeking University First Hospital, Beijing, China.
Nathalie J LambrechtDepartment of Nutritional Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Yaping JiangPeking University First Hospital, Beijing, China.
Jingmin WangPeking University First Hospital, Beijing, China.
Margit BurmeisterDepartment of Computational Medicine & Bioinformatics, Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA.
Ming LiPeking University First Hospital, Beijing, China.
Betsy LozoffDepartment of Pediatrics, Medical School, University of Michigan, Ann Arbor, MI, USA.
Peking University · CNUniversity of Michigan · US

Funding

Timing, Duration and Severity of Infant Iron Deficiency: Developmental ImpactsR01HD052069 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LOZOFF, BETSY · 2007 to 2011
$3.9M
NICHD NIH HHS R01 HD052069
6 · The paper itself

Abstract

backgroundOverweight or obesity among pregnant women may compromise maternal and neonatal iron status by upregulating hepcidin.

objectivesThis study determined the association of 1) maternal and neonatal iron status with maternal and neonatal hepcidin concentrations, and 2) maternal prepregnancy weight status with maternal and neonatal hepcidin concentrations.

methodsWe examined hematologic data from 405 pregnant women and their infants from the placebo treatment group of a pregnancy iron supplementation trial in rural China. We measured hepcidin, serum ferritin (SF), soluble transferrin receptor (sTfR), and high-sensitivity C-reactive protein in maternal blood samples at mid-pregnancy and in cord blood at delivery. We used regression analysis to examine the association of maternal prepregnancy overweight or obese status with maternal hepcidin concentration in mid-pregnancy and cord hepcidin concentrations. We also used path analysis to examine mediation of the association of maternal prepregnancy overweight or obese status with maternal iron status by maternal hepcidin, as well as with neonatal hepcidin by neonatal iron status.

resultsMaternal iron status was positively correlated with maternal hepcidin at mid-pregnancy (SF: r = 0.63, P < 0.001; sTfR: r = -0.37, P < 0.001). Neonatal iron status was also positively correlated with cord hepcidin (SF: r = 0.61, P < 0.001; sTfR: r = -0.39, P < 0.001). In multiple linear regression models, maternal prepregnancy overweight or obese status was not associated with maternal hepcidin at mid-pregnancy but was associated with lower cord hepcidin (coefficient = -0.21, P = 0.004). Using path analysis, we observed a significant indirect effect of maternal prepregnancy overweight or obese status on cord hepcidin, mediated by neonatal iron status.

conclusionsIn both pregnant women and neonates, hepcidin was responsive to iron status. Maternal prepregnancy overweight status, with or without including obese women, was associated with lower cord blood hepcidin, likely driven by lower iron status among the neonates of these mothers.

Indexed as

HepcidinsOverweightFemaleFerritinsHumansInfant, NewbornObesityPregnancyReceptors, TransferrinFerritinsHepcidinsReceptors, TransferrinChinahepcidiniron deficiencyobesitypregnancy

Identifiers

PMID33979838
PMCPMC8349130
OpenAlexW3160128241

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.