Evidence map›Paper›PMID 33980115›Full record

ArticleThe journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians2022

Metabolic differences among newborns born to mothers with a history of leukemia or lymphoma.

Sonia T Anand, Kelli K Ryckman, Rebecca J Baer, Mary E Charlton, Patrick J Breheny, William W Terry, Kord Kober, Scott Oltman, Elizabeth E Rogers, Laura L Jelliffe-Pawlowski and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Sonia T AnandDepartment of Epidemiology, University of Iowa, Iowa City, IA, USA.ORCID 0000-0002-5494-1821
Kelli K RyckmanDepartment of Epidemiology, University of Iowa, Iowa City, IA, USA.
Rebecca J BaerDepartment of Pediatrics, University of California San Diego, La Jolla, CA, USA.
Mary E CharltonDepartment of Epidemiology, University of Iowa, Iowa City, IA, USA.
Patrick J BrehenyDepartment of Biostatistics, University of Iowa, Iowa City, IA, USA.
William W TerryDepartment of Pediatrics, University of Iowa, Iowa City, IA, USA.
Kord KoberDepartment of Physiological Nursing, University of California San Francisco, San Francisco, CA, USA.
Scott OltmanCalifornia Preterm Birth Initiative, University of California San Francisco, San Francisco, CA, USA.
Elizabeth E RogersCalifornia Preterm Birth Initiative, University of California San Francisco, San Francisco, CA, USA.
Laura L Jelliffe-PawlowskiCalifornia Preterm Birth Initiative, University of California San Francisco, San Francisco, CA, USA.
Elizabeth A ChrischillesDepartment of Epidemiology, University of Iowa, Iowa City, IA, USA.
University of Iowa · USUniversity of California, San Francisco · US

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Jon C.D. Houtman · 2000 to 2026
$70.0M
NCI NIH HHS P30 CA086862
6 · The paper itself

Abstract

backgroundLeukemia and lymphoma are cancers affecting children, adolescents, and young adults and may affect reproductive outcomes and maternal metabolism. We evaluated for metabolic changes in newborns of mothers with a history of these cancers.

methodsA cross-sectional study was conducted on California births from 2007 to 2011 with linked maternal hospital discharge records, birth certificate, and newborn screening metabolites. History of leukemia or lymphoma was determined using ICD-9-CM codes from hospital discharge data and newborn metabolite data from the newborn screening program.

resultsA total of 2,068,038 women without cancer history and 906 with history of leukemia or lymphoma were included. After adjusting for differences in maternal age, infant sex, age at metabolite collection, gestational age, and birthweight, among newborns born to women with history of leukemia/lymphoma, several acylcarnitines were significantly (

conclusionThe varied metabolite levels suggest history of leukemia or lymphoma has metabolic impact on newborn offspring, which may have implications for future metabolic consequences such as necrotizing enterocolitis and urea cycle enzyme disorders in children born to mothers with a history of leukemia or lymphoma.

Indexed as

LeukemiaLymphomaAdolescentChildCross-Sectional StudiesFemaleGestational AgeHumansInfant, NewbornMothersYoung Adultacylcarnitinesamino acidLeukemialymphomametabolitenewborn

Identifiers

PMID33980115
PMCPMC8586052
OpenAlexW3162737041

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.